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Titolo:
Regulation of sensorimotor gating of the startle reflex by serotonin 2A receptors: Ontogeny and strain differences
Autore:
Farid, M; Martinez, ZA; Geyer, MA; Swerdlow, NR;
Indirizzi:
Univ Calif San Diego, Sch Med, Dept Psychiat, La Jolla, CA 92093 USA Univ Calif San Diego La Jolla CA USA 92093 ychiat, La Jolla, CA 92093 USA
Titolo Testata:
NEUROPSYCHOPHARMACOLOGY
fascicolo: 6, volume: 23, anno: 2000,
pagine: 623 - 632
SICI:
0893-133X(200012)23:6<623:ROSGOT>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
PREPULSE INHIBITION; ACOUSTIC STARTLE; SCHIZOPHRENIC-PATIENTS; ANIMAL-MODEL; RAT STRAINS; MODULATION; HABITUATION; APOMORPHINE; DISRUPTION; DOI;
Keywords:
prepulse inhibition; schizophrenia; sensorimotor; regulation; serotonin; startle; strain differences;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Swerdlow, NR Univ Calif San Diego, Sch Med, Dept Psychiat, 0804,9500 Gilman Dr, La Jolla, CA 92093 USA Univ Calif San Diego 0804,9500 Gilman Dr La Jolla CA USA 92093
Citazione:
M. Farid et al., "Regulation of sensorimotor gating of the startle reflex by serotonin 2A receptors: Ontogeny and strain differences", NEUROPSYCH, 23(6), 2000, pp. 623-632

Abstract

Sensorimotor gating of the startle reflex can be assessed via measures of prepulse inhibition (PPI), which is the reduction in startle magnitude whenthe startling stimulus is preceded immediately by a weak prepulse. PPI is reduced in humans with specific neuropsychiatric disorders and in rats after treatment with certain classes of drugs, including serotonin (5-HT) agonists. Because of the relative loss of PPI in inherited, neurodevelopment in disorders such as schizophrenia, there is great interest in understanding the inherited and developmental features of the neurochemical regulation of PPI in animals. In the present study, PPI was disrupted significantly by the 5-HT2A agonist 2,5-dimethoxy-4 iodopheny-lisopropylamine (DOI) in SpragueDawley (SDH) and Wistar rat strains (WH). While it was demonstrated that the DOI effects in SDH rats reflected an unequivocal disruption of sensorimotor gating, in WH rats, reduced PPI was observed in the context of a trend for a DOI-induced reduction in startle magnitude. This effect of DOI in SDHmis was evident at the earliest date tested (17 days of age) in male pups,brit tons not statistically significant in female pups. Thus, the regulation of sensorimotor gating by 5-HT2A receptor stimulation in mts may exhibitsubtle differences across strains, and within SDH rats, between sexes. Most importantly, the 5-HT2A regulation of sensorimotor gating in male SDH rats is a "phenotype" that is expressed very early in life, and is sustained through adulthood. (C) 2000 American College of Neuropsychopharmacology. Published by Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 22:00:55