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Titolo:
Functional neuroimaging: Enhanced understanding of migraine pathophysiology
Autore:
Cutrer, FM; ODonnell, A; del Rio, MS;
Indirizzi:
Brigham & Womens Hosp, Massachusetts Gen Hosp, Partners Headdache Ctr, Dept Neurol, Boston, MA USA Brigham & Womens Hosp Boston MA USA che Ctr, Dept Neurol, Boston, MA USA Brigham & Womens Hosp, Massachusetts Gen Hosp, Partners Headdache Ctr, Dept Neurosurg, Boston, MA USA Brigham & Womens Hosp Boston MA USA Ctr, Dept Neurosurg, Boston, MA USA
Titolo Testata:
NEUROLOGY
fascicolo: 9, volume: 55, anno: 2000, supplemento:, 2
pagine: S36 - S45
SICI:
0028-3878(200011)55:9<S36:FNEUOM>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBRAL BLOOD-FLOW; TRANSCRANIAL MAGNETIC STIMULATION; BASILAR ARTERY MIGRAINE; BRAIN ENERGY-METABOLISM; CLASSIC MIGRAINE; SPREADING DEPRESSION; CEREBROVASCULAR REACTIVITY; DOPPLER SONOGRAPHY; OXYGEN-METABOLISM; AURA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
63
Recensione:
Indirizzi per estratti:
Indirizzo: Cutrer, FM Massachusetts Gen Hosp, 149 13th St,CNY 6403, Charlestown, MA 02129 USA Massachusetts Gen Hosp 149 13th St,CNY 6403 Charlestown MA USA 02129
Citazione:
F.M. Cutrer et al., "Functional neuroimaging: Enhanced understanding of migraine pathophysiology", NEUROLOGY, 55(9), 2000, pp. S36-S45

Abstract

Research into migraine pathophysiology has been hampered by the episodic nature and unpredictable onset of migraine attacks. Recently, newer imaging techniques have been providing noninvasive methods of studying metabolism and hemodynamics in the brains of migraineurs during and between acute attacks. Xe-133 blood flow techniques, transcranial Doppler, and SPECT have all been employed to investigate hemodynamic changes during migraine aura. PET has been useful in the study of migraine without aura, with findings of increased blood flow related to pain in cortical areas and in the medial brainstem. Currently, three functional MRI imaging techniques are being used in migraine research. Diffusion-weighted imaging has shown normal findings in measures of the ability of neurons to maintain osmotic gradients. Studies using perfusion-weighted imaging have shown alterations in relative cerebralblood flow (CBF), relative cerebral blood volume, and mean transit time during migraine visual aura. The blood oxygen level-dependent technique can supply information related to neuronal activation during acute migraine aura. MRS has been used with mixed success to look for evidence of abnormal energy metabolism in the brains of migraineurs. Magnetoencephalography studiessupport the presence of a spreading depression-like phenomenon in migrainewith aura. Two groups have used transcranial magnetic stimulation to assess whether neurons in the occipital cortex are hyperexcitable, predisposing patients to develop aura symptoms. Despite conflicting findings, migraine with visual aura appears to be generally associated with transient decreasesin regional CBF.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 00:34:46