Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Reduced leptin levels in human narcolepsy
Autore:
Schuld, A; Blum, WF; Uhr, M; Haack, M; Kraus, T; Holsboer, F; Pollmacher, T;
Indirizzi:
Max Planck Inst Psychiat, D-80804 Munich, Germany Max Planck Inst Psychiat Munich Germany D-80804 D-80804 Munich, Germany Lilly Deutschland GmbH, Bad Homburg, Germany Lilly Deutschland GmbH Bad Homburg Germany d GmbH, Bad Homburg, Germany Univ Giessen, Childrens Hosp, Giessen, Germany Univ Giessen Giessen Germany Giessen, Childrens Hosp, Giessen, Germany
Titolo Testata:
NEUROENDOCRINOLOGY
fascicolo: 4, volume: 72, anno: 2000,
pagine: 195 - 198
SICI:
0028-3835(200010)72:4<195:RLLIHN>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
REM-SLEEP; OREXINS;
Keywords:
hypocretins; orexins; obesity; sleep; cataplexy; leptin; clinical neuroendocrinology;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Schuld, A Max Planck Inst Psychiat, Kraepelinstr 10, D-80804 Munich, Germany Max Planck Inst Psychiat Kraepelinstr 10 Munich Germany D-80804
Citazione:
A. Schuld et al., "Reduced leptin levels in human narcolepsy", NEUROENDOCR, 72(4), 2000, pp. 195-198

Abstract

Recently, hypocretins have been implicated in the pathophysiology of narcolepsy, a sleep disorder characterized particularly by the occurrence of excessive daytime sleepiness and cataplexy. Hypocretins, which stimulate food intake, have been reported to be absent in the cerebrospinal fluid (CSF) ofthe majority of patients suffering from narcolepsy. Because these patientsalso display an increased body mass index (BMI), it has been suggested that disturbances in metabolism and food intake regulation may be present. To further investigate these presumed alterations, we studied the production of leptin, a fat-cell-derived hormone signaling to the brain the size of theadipose tissue. We measured the levels of leptin in serum and CSF from 15 narcoleptic patients and compared the results to those from age-, sex- and BMI-matched control groups of depressive patients and patients suffering from a noninflammatory neurological disorder. Compared to both control groups, leptin levels in serum, but not in the CSF, were significantly reduced innarcoleptic patients by more than 50%. These results support the hypothesis that human narcolepsy is accompanied by complex alterations of the regulation of food intake and metabolism. The significance of these alterations for the core symptomatology of narcolepsy should be a target of future research. Copyright (C) 2000 S. Karger AG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/02/20 alle ore 15:10:19