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Titolo:
Dopamine D1 receptor protein is elevated in nucleus accumbens of human, chronic methamphetamine users
Autore:
Worsley, JN; Moszczynska, A; Falardeau, P; Kalasinsky, KS; Schmunk, G; Guttman, M; Furukawa, Y; Ang, L; Adams, V; Reiber, G; Anthony, RA; Wickham, D; Kish, SJ;
Indirizzi:
Ctr Addict & Mental Hlth, Human Neurochem Pathol Lab, Toronto, ON M5T 1R8,Canada Ctr Addict & Mental Hlth Toronto ON Canada M5T 1R8 nto, ON M5T 1R8,Canada Univ Laval, CHUQ, Ctr Rech, Neurosci Unit, Quebec City, PQ G1V 4G2, CanadaUniv Laval Quebec City PQ Canada G1V 4G2 Quebec City, PQ G1V 4G2, Canada Armed Forces Inst Pathol, Div Forens Toxicol, Washington, DC 20306 USA Armed Forces Inst Pathol Washington DC USA 20306 Washington, DC 20306 USA Off Santa Clara Cty Med Examiner Coroner, San Jose, CA 95128 USA Off SantaClara Cty Med Examiner Coroner San Jose CA USA 95128 95128 USA Sunnybrook Hosp, Dept Pathol Neuropathol, Toronto, ON M4N 3M5, Canada Sunnybrook Hosp Toronto ON Canada M4N 3M5 ol, Toronto, ON M4N 3M5, Canada Off Hillsborough Cty Med Examiner, Tampa, FL 33602 USA Off Hillsborough Cty Med Examiner Tampa FL USA 33602 Tampa, FL 33602 USA Clark Cty Med Examiner Off, Vancouver, WA 98660 USA Clark Cty Med ExaminerOff Vancouver WA USA 98660 Vancouver, WA 98660 USA
Titolo Testata:
MOLECULAR PSYCHIATRY
fascicolo: 6, volume: 5, anno: 2000,
pagine: 664 - 672
SICI:
1359-4184(200011)5:6<664:DDRPIE>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
COCAINE-SEEKING BEHAVIOR; HUNTINGTONS-DISEASE; SIGNAL-TRANSDUCTION; STRIATAL DOPAMINE; HUMAN BRAIN; BINDING; D-1; INCREASE; SYSTEM; PET;
Keywords:
methamphetamine; cocaine; heroin; dopamine; nucleus accumbens; dopamine D1 receptor; dopamine D2 receptor; addiction;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Kish, SJ Ctr Addict & Mental Hlth, Human Neurochem Pathol Lab, 250 Coll St, Toronto, ON M5T 1R8, Canada Ctr Addict & Mental Hlth 250 Coll St Toronto ON Canada M5T 1R8 da
Citazione:
J.N. Worsley et al., "Dopamine D1 receptor protein is elevated in nucleus accumbens of human, chronic methamphetamine users", MOL PSYCHI, 5(6), 2000, pp. 664-672

Abstract

Animal data have long suggested that an adaptive upregulation of nucleus accumbens dopamine D1 receptor function might underlie part of the dependency on drugs of abuse. We measured by quantitative immunoblotting protein levels of dopamine DI and, for comparison, D2 receptors in brain of chronic users of methamphetamine, cocaine, and heroin. As compared with the controls,brain dopamine DI receptor concentrations were selectively increased (by 44%) in the nucleus accumbens of the methamphetamine users, whereas a trend was observed in this brain area for reduced protein levels of the dopamine D2 receptor in all three drug groups (-25 to -37%; P < 0.05 for heroin group only). Our data support the hypothesis that aspects of the drug-dependentstate in human methamphetamine users might be related to increased dopamine D1 receptor function in limbic brain.

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Documento generato il 25/01/20 alle ore 19:02:31