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Titolo:
Acetyl-L-carnitine physical-chemical, metabolic, and therapeutic properties: relevance for its mode of action in Alzheimer's disease and geriatric depression
Autore:
Pettegrew, JW; Levine, J; McClure, RJ;
Indirizzi:
Univ Pittsburgh, Sch Med, Dept Psychiat, Neurophys Lab, Pittsburgh, PA USAUniv Pittsburgh Pittsburgh PA USA iat, Neurophys Lab, Pittsburgh, PA USA Ben Gurion Univ Negev, Fac Hlth Sci, Beersheva Mental Hlth Ctr, Beer Sheva, Israel Ben Gurion Univ Negev Beer Sheva Israel al Hlth Ctr, Beer Sheva, Israel
Titolo Testata:
MOLECULAR PSYCHIATRY
fascicolo: 6, volume: 5, anno: 2000,
pagine: 616 - 632
SICI:
1359-4184(200011)5:6<616:APMATP>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
NERVE GROWTH-FACTOR; CHOLINE-ACETYLTRANSFERASE ACTIVITY; CEREBRAL MITOCHONDRIAL POPULATIONS; MAGNETIC-RESONANCE SPECTROSCOPY; ACETYLCHOLINE-RECEPTOR CLUSTERS; RANDOMIZED CONTROLLED TRIAL; FIMBRIA-FORNIX TRANSECTION; NORMAL HUMAN-ERYTHROCYTES; PLACEBO-CONTROLLED TRIAL; BRAIN ENERGY-METABOLISM;
Keywords:
Alzheimer's disease; geriatric depression; acetyl-L-carnitine; lipid metabolism; energy metabolism; membrane; acetylation;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
202
Recensione:
Indirizzi per estratti:
Indirizzo: Pettegrew, JW Univ Pittsburgh, Grad Sch Publ Hlth, Neurol & Hlth Serv Adm,Neurophys Lab, A741 Crabtree Hall,130 De Soto St, Pittsburgh, PA 15213 USAUniv Pittsburgh A741 Crabtree Hall,130 De Soto St Pittsburgh PA USA 15213
Citazione:
J.W. Pettegrew et al., "Acetyl-L-carnitine physical-chemical, metabolic, and therapeutic properties: relevance for its mode of action in Alzheimer's disease and geriatric depression", MOL PSYCHI, 5(6), 2000, pp. 616-632

Abstract

Acetyl-L-carnitine (ALCAR) contains carnitine and acetyl moieties, both ofwhich have neurobiological properties. Carnitine is important in the p-oxidation of fatty acids and the acetyl moiety can be used to maintain acetyl-CoA levels, Other reported neurobiological effects of ALCAR include modulation of: (1) brain energy and phospholipid metabolism; (2) cellular macromolecules, including neurotrophic factors and neurohormones; (3) synaptic morphology; and (4) synaptic transmission of multiple neurotransmitters. Potential molecular mechanisms of ALCAR activity include: (1) acetylation of -NH2and -OH functional groups in amino acids and N terminal amino acids in peptides and proteins resulting in modification of their structure, dynamics, function and turnover; and (2) acting as a molecular chaperone to larger molecules resulting in a change in the structure, molecular dynamics, and function of the larger molecule, ALCAR is reported in double-blind controlled studies to have beneficial effects in major depressive disorders and Alzheimer's disease (AD), both of which are highly prevalent in the geriatric population.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 19:45:14