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Titolo:
Essential roles for Caenorhabditis elegans lamin gene in nuclear organization, cell cycle progression, and spatial organization of nuclear pore complexes
Autore:
Liu, J; Ben-Shahar, TR; Riemer, D; Treinin, M; Spann, P; Weber, K; Fire, A; Gruenbaum, Y;
Indirizzi:
Hebrew Univ Jerusalem, Inst Life Sci, Dept Genet, IL-91904 Jerusalem, Israel Hebrew Univ Jerusalem Jerusalem Israel IL-91904 -91904 Jerusalem, Israel Carnegie Inst Washington, Dept Embryol, Baltimore, MD 21210 USA Carnegie Inst Washington Baltimore MD USA 21210 , Baltimore, MD 21210 USA Max Planck Inst Biophys Chem, Dept Biochem, D-37077 Gottingen, Germany MaxPlanck Inst Biophys Chem Gottingen Germany D-37077 ottingen, Germany Hebrew Univ Jerusalem, Hadassah Med Sch, Dept Physiol, IL-91120 Jerusalem,Israel Hebrew Univ Jerusalem Jerusalem Israel IL-91120 L-91120 Jerusalem,Israel
Titolo Testata:
MOLECULAR BIOLOGY OF THE CELL
fascicolo: 11, volume: 11, anno: 2000,
pagine: 3937 - 3947
SICI:
1059-1524(200011)11:11<3937:ERFCEL>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
MATRIX ATTACHMENT REGIONS; CHROMATIN BINDING-SITE; A-TYPE LAMIN; MUSCULAR-DYSTROPHY; ANNULATE LAMELLAE; CDNA CLONING; TAIL DOMAIN; FREE SYSTEM; ROD DOMAIN; C-ELEGANS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
53
Recensione:
Indirizzi per estratti:
Indirizzo: Gruenbaum, Y Hebrew Univ Jerusalem, Inst Life Sci, Dept Genet, IL-91904 Jerusalem, Israel Hebrew Univ Jerusalem Jerusalem Israel IL-91904 lem, Israel
Citazione:
J. Liu et al., "Essential roles for Caenorhabditis elegans lamin gene in nuclear organization, cell cycle progression, and spatial organization of nuclear pore complexes", MOL BIOL CE, 11(11), 2000, pp. 3937-3947

Abstract

Caenorhabditis elegans has a single lamin gene, designated lmn-1 (previously termed CeLam-1). Antibodies raised against the lmn-1 product (Ce-lamin) detected a 64-kDa nuclear envelope protein. Ce-lamin was detected in the nuclear periphery of all cells except sperm and was found in the nuclear interior in embryonic cells and in a fraction of adult cells. Reductions in theamount of Ce-lamin protein produce embryonic lethality. Although the majority of affected embryos survive to produce several hundred nuclei, defects can be detected as early as the first nuclear divisions. Abnormalities include rapid changes in nuclear morphology during interphase, loss of chromosomes, unequal separation of chromosomes into daughter nuclei, abnormal condensation of chromatin, an increase in DNA content, and abnormal distributionof nuclear pore complexes (NPCs). Under conditions of incomplete RNA interference, a fraction of embryos escaped embryonic arrest and continue to develop through larval life. These animals exhibit additional phenotypes including sterility and defective segregation of chromosomes in germ cells. Our observations show that: lmn-1 is an essential gene in C, elegans, and that the nuclear lamins are involved in chromatin organization, cell cycle progression, chromosome segregation, and correct spacing of NPCs.

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Documento generato il 05/04/20 alle ore 06:56:52