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Titolo:
Lessons from tumor and immunocompetent cells - The quantitative engagementof ligand-receptor interactions modulates stop-and-go behaviour as well asproliferation
Autore:
Dittmar, T; Brandt, BH; Lang, K; Zaenker, KS; Entschladen, F;
Indirizzi:
Univ Witten Herdecke, Inst Immunol, D-58448 Witten, Germany Univ Witten Herdecke Witten Germany D-58448 nol, D-58448 Witten, Germany Univ Munster, Inst Clin Chem & Lab Med, D-4400 Munster, Germany Univ Munster Munster Germany D-4400 m & Lab Med, D-4400 Munster, Germany
Titolo Testata:
MEDICINA-BUENOS AIRES
, volume: 60, anno: 2000, supplemento:, 2
pagine: 27 - 33
SICI:
0025-7680(2000)60:<27:LFTAIC>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROWTH-FACTOR RECEPTOR; BREAST-CANCER CELLS; NEUTROPHIL MIGRATION; OVEREXPRESSION; CHEMOKINES; LOCOMOTION;
Keywords:
chemokines; chemotaxis; growth substances; oncogenes; protein-tyrosine kinase; cell movement;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Dittmar, T Univ Witten Herdecke, Inst Immunol, Stockumer Str 10, D-58448 Witten, Germany Univ Witten Herdecke Stockumer Str 10 Witten Germany D-58448 y
Citazione:
T. Dittmar et al., "Lessons from tumor and immunocompetent cells - The quantitative engagementof ligand-receptor interactions modulates stop-and-go behaviour as well asproliferation", MEDICINA, 60, 2000, pp. 27-33

Abstract

The four main cell functions, proliferation, apoptosis, differentiation and migration, are tightly regulated by external signals that initiate intracellular signal transduction pathways and determine the cellular behaviour. The concentration and composition of such external signals are at least important for the decision of cells as to which function has to be executed. Interleukin-8 is a well known inducing signal for neutrophil granulocyte migration, while the epidermal growth factor is an inducing signal for breast carcinoma cell migration. Depending on the concentrations of interleukin-8,the neutrophil granulocytes are capable of migration. However, at high concentration of interleukin-8 the migratory activity of each single cell is reduced, indicating that high concentrations of the chemokine inhibit migration and promote the performance of other cell functions. Concerning breast carcinoma cells, the epidermal growth factor is not only an inducer of migration but also an inhibitor of proliferation. These two examples provide evidence for a dose dependent action of external signals for several cell functions in parallel. This versatility of the effects of one ligand might be based on several intracellular signal transduction pathways that are turnedon. For the dose-dependent differences of the effect of interleukin-8 we propose a two wheel model of an inositolphosphate-mediated, ATP-independent release of calcium from intracellular stores and a cyclic AMP-mediated, ATP-dependent uptake of calcium into the endoplasmatic reticulum.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 10:59:19