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Titolo:
Age-related decreases in lymphocyte protein kinase C activity and translocation are reduced by aerobic fitness
Autore:
Wang, HY; Bashore, TR; Tran, ZV; Friedman, E;
Indirizzi:
MCP Hahnemann Sch Med, Dept Pharmacol & Physiol, Philadelphia, PA 19102 USA MCP Hahnemann Sch Med Philadelphia PA USA 19102 hiladelphia, PA 19102 USA Univ No Colorado, Dept Psychol, Greeley, CO 80639 USA Univ No Colorado Greeley CO USA 80639 Dept Psychol, Greeley, CO 80639 USA Moss Rehabil Res Inst, Philadelphia, PA USA Moss Rehabil Res Inst Philadelphia PA USA Res Inst, Philadelphia, PA USA Univ Colorado, Hlth Sci Ctr, Dept Prevent Med & Biometr, Denver, CO 80262 USA Univ Colorado Denver CO USA 80262 ent Med & Biometr, Denver, CO 80262 USA
Titolo Testata:
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
fascicolo: 11, volume: 55, anno: 2000,
pagine: B545 - B551
SICI:
1079-5006(200011)55:11<B545:ADILPK>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
D2 DOPAMINE RECEPTOR; RAT-BRAIN; T-CELL; SIGNAL-TRANSDUCTION; ACTIVATION; EXERCISE; RELEASE; SYNAPTOSOMES; BINDING; CALCIUM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Friedman, E MCP Hahnemann Sch Med, Dept Pharmacol & Physiol, Mailbox 488,245 N 15th St, Philadelphia, PA 19102 USA MCP Hahnemann Sch Med Mailbox 488,245 N 15th St Philadelphia PA USA 19102
Citazione:
H.Y. Wang et al., "Age-related decreases in lymphocyte protein kinase C activity and translocation are reduced by aerobic fitness", J GERONT A, 55(11), 2000, pp. B545-B551

Abstract

This study investigated the effects of advancing age and long-term aerobicfitness on lymphocyte protein kinase C (PKC) activity and translocation. Lymphocytes were obtained from young (20-36 years old) and older (61-78 years old) healthy men who were either aerobically conditioned or deconditioned. Both baseline PKC activity and the response of this enzyme to the direct PKC stimulating agent, phorbol 12-myristate, 13-acetate (PMA) or to the mitogen, phytohaemagglutinin (PNA), were measured in partially purified extracts of cytosolic and membranous fractions of lymphocytes. Basal PKC activity, PMA-induced redistribution of PKC, and PHA-induced enhancement of PKC activity were reduced among older subjects in both lymphocyte cytosolic and membranous fractions. However, the magnitudes of these reductions were smaller among the older subjects who were aerobically fit. Lymphocyte PKC activity and translocation may be biological markers of aging, and the maintenanceof aerobic fitness into later life mag. serve to slow the rate at which activation of this enzyme declines during senescence.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/20 alle ore 15:30:32