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Titolo:
Changes in anesthetic sensitivity and glutamate receptors in the aging canine brain
Autore:
Magnusson, KR; Scanga, C; Wagner, AE; Dunlop, C;
Indirizzi:
Colorado State Univ, Coll Vet Med & Biomed Sci, Dept Anat & Neurobiol, Ft Collins, CO 80523 USA Colorado State Univ Ft Collins CO USA 80523 iol, Ft Collins, CO 80523 USA Colorado State Univ, Coll Vet Med & Biomed Sci, Dept Clin Sci, Ft Collins,CO 80523 USA Colorado State Univ Ft Collins CO USA 80523 Sci, Ft Collins,CO 80523 USA Adv Anaesthesia Specialists, N Ryde, NSW, Australia Adv Anaesthesia Specialists N Ryde NSW Australia N Ryde, NSW, Australia
Titolo Testata:
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
fascicolo: 9, volume: 55, anno: 2000,
pagine: B448 - B454
SICI:
1079-5006(200009)55:9<B448:CIASAG>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
H-3 MK-801 BINDING; AMINO-ACID BINDING; AGED RATS; INVITRO AUTORADIOGRAPHY; VOLATILE ANESTHETICS; DIETARY RESTRICTION; FRONTAL-CORTEX; C57B1 MICE; NMDA; COMPLEX;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Magnusson, KR Colorado State Univ, Coll Vet Med & Biomed Sci, Dept Anat & Neurobiol, Ft Collins, CO 80523 USA Colorado State Univ Ft Collins CO USA 80523 s, CO 80523 USA
Citazione:
K.R. Magnusson et al., "Changes in anesthetic sensitivity and glutamate receptors in the aging canine brain", J GERONT A, 55(9), 2000, pp. B448-B454

Abstract

This study investigated whether the aging process in dogs is associated with an increased sensitivity to inhalation anesthesia and whether age-related changes in glutamate receptors are related to the increased sensitivity. The mean minimum alveolar concentration (MAC) of isoflurane was 1.82 +/- .08% for 2-3 year olds and 1.45 +/- .06% for 11 Sears olds, indicating that there was an increased potency of isoflurane in the older dogs as compared to the young. These older animals also showed a significant decrease in binding of [H-3]glutamate and [H-3]dizocilpine ([H-3]MK801) to N-methyl-D-aspartate (NMDA) receptors in multiple cortical and hippocampal regions. The density of binding to NMDA receptors in the cortex, using a single concentration of ligand, correlated significantly with individual MAC values. These results demonstrate that dogs experience an increase in anesthetic potency with increased age, similar to humans, and that age-related changes in the NMDA receptor may represent one mechanism underlying this increased sensitivity to anesthesia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 08:09:10