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Titolo:
Cerebrospinal fluid beta(2)-microglobulin in neuro-Behcet's syndrome
Autore:
Kawai, M; Hirohata, S;
Indirizzi:
Teikyo Univ, Sch Med, Dept Internal Med, Itabashi Ku, Tokyo 1738605, JapanTeikyo Univ Tokyo Japan 1738605 l Med, Itabashi Ku, Tokyo 1738605, Japan
Titolo Testata:
JOURNAL OF THE NEUROLOGICAL SCIENCES
fascicolo: 1-2, volume: 179, anno: 2000,
pagine: 132 - 139
SICI:
0022-510X(20001001)179:1-2<132:CFBINS>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
NERVOUS-SYSTEM INVOLVEMENT; NEUROLOGICAL DISORDERS; IGG ANALYSES; DISEASE; BETA-2-MICROGLOBULIN; INTERLEUKIN-6; PRINCIPLES; LYSOZYME; ALBUMIN;
Keywords:
Behcet's disease; cerebrospinal fluid; IL-6; beta(2)-microglobulin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Hirohata, S Teikyo Univ, Sch Med, Dept Internal Med, Itabashi Ku, 2-11-1 Kaga, Tokyo 1738605, Japan Teikyo Univ 2-11-1 Kaga Tokyo Japan 1738605 yo 1738605, Japan
Citazione:
M. Kawai e S. Hirohata, "Cerebrospinal fluid beta(2)-microglobulin in neuro-Behcet's syndrome", J NEUR SCI, 179(1-2), 2000, pp. 132-139

Abstract

Paired serum and cerebrospinal fluid (CSF) specimens from 17 patients withBehcet's disease and central nervous system (CNS) involvement (neuro-Behcet's syndrome; NE) were studied for beta (2)-microglobulin (beta (2)MG) and albumin, using ELISA and single radial immunodiffusion, respectively. We also studied 29 patients with non-inflammatory neurological diseases for comparison. All of CSF beta (2)MG, serum beta (2)MG, Q albumin tan indicator ofblood-brain barrier function), and CSF beta (2)MG index (an indicator of intrathecal beta (2)MG synthesis) were significantly elevated in patients with NE compared with the control patients. There were no significant differences in these parameters between 11 patients with chronic NB and six patients with acute NE. In nine patients with NB, CSF beta (2)MG and Q albumin were significantly decreased when the CNS manifestations were improved by successful treatment, whereas CSF beta (2)MG index and serum beta (2)MG were not significantly changed. The results indicate that the elevation of CSF beta (2)MG, which results from the transudation of serum beta (2)MG as well as the increased intrathecal synthesis presumably by infiltrating lymphocytes, is a good marker of CNS disease activity of NE. The data, however, also suggest that the intrathecal synthesis of beta (2)MG might not parallel to the CNS disease activity of NE, most likely due to the recovery of constitutive physiological intrathecal synthesis of beta (2)MG in spite of the withdrawal of pathological beta (2)MG synthesis at times of treatment-associated improvement. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/02/20 alle ore 13:50:42