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Titolo:
Neurobehavioural consequences of substance abuse and HIV infection
Autore:
Basso, MR; Bornstein, RA;
Indirizzi:
Univ Tulsa, Dept Psychol, Tulsa, OK 74104 USA Univ Tulsa Tulsa OK USA 74104 iv Tulsa, Dept Psychol, Tulsa, OK 74104 USA Ohio State Univ, Med Ctr, Dept Psychiat, Columbus, OH 43210 USA Ohio StateUniv Columbus OH USA 43210 pt Psychiat, Columbus, OH 43210 USA Ohio State Univ, Med Ctr, Dept Neurol, Columbus, OH 43210 USA Ohio State Univ Columbus OH USA 43210 Dept Neurol, Columbus, OH 43210 USA
Titolo Testata:
JOURNAL OF PSYCHOPHARMACOLOGY
fascicolo: 3, volume: 14, anno: 2000,
pagine: 228 - 237
SICI:
0269-8811(200009)14:3<228:NCOSAA>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBRAL BLOOD-FLOW; HUMAN-IMMUNODEFICIENCY-VIRUS; POSITRON-EMISSION-TOMOGRAPHY; INTRAVENOUS-DRUG-USERS; ABSTINENT COCAINE ABUSERS; ILLICIT AMPHETAMINE USERS; BRAIN GLUCOSE-METABOLISM; NEUROPSYCHOLOGICAL PERFORMANCE; IMMUNE-SYSTEM; ALCOHOL-ABUSE;
Keywords:
AIDS; basal ganglia; brain; cocaine; dementia; dopamine; HIV; methamphetamine; neuroleptics; opiates; Parkinson's disease;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
121
Recensione:
Indirizzi per estratti:
Indirizzo: Basso, MR Univ Tulsa, Dept Psychol, 600 S Coll Ave, Tulsa, OK 74104 USA Univ Tulsa 600 S Coll Ave Tulsa OK USA 74104 Tulsa, OK 74104 USA
Citazione:
M.R. Basso e R.A. Bornstein, "Neurobehavioural consequences of substance abuse and HIV infection", J PSYCHOPH, 14(3), 2000, pp. 228-237

Abstract

Although our understanding of how human immunodefiency virus (HIV)-relatedneurobehavioural deficits develop is nascent and preliminary, some clues have emerged which may clarify lingering uncertainties. In particular, HIV seems to yield brain dysfunction by mediating pathological changes upon neuronal function. HIV also compromises immunological integrity, thereby resulting in secondary infections that may further increase brain dysfunction. Notably, many individuals with HIV tend to be current or past abusers of drugs, and, in some cases, their drug use may have actually presented a pathwayfor initial HIV infection. Similar to HIV, many drugs tend to yield pathological changes upon neuronal function. Further paralleling HIV, some drugs seem to compromise immune function, which in turn may yield secondary detrimental effects upon the brain. Yet, despite the relatively high comorbidityrates of HIV infection and substance abuse, few investigations have addressed the potential interaction between these two factors upon neurobehavioural status. Towards this end, the present paper reviews the existing literature concerning neuropsychological effects of HIV and substance use, and suggests potential mechanisms whereby substance use may potentiate and exacerbate the onset and severity of neurobehavioural abnormalities in HIV infection.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 11:49:15