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Titolo:
Neurotoxicity and dysfunction of dopaminergic systems associated with AIDSdementia
Autore:
Nath, A; Anderson, C; Jones, M; Maragos, W; Booze, R; Mactutus, C; Bell, J; Hauser, KF; Mattson, M;
Indirizzi:
Univ Kentucky, Dept Neurol, Lexington, KY 40506 USA Univ Kentucky Lexington KY USA 40506 Dept Neurol, Lexington, KY 40506 USA Univ Kentucky, Dept Microbiol & Immunol, Lexington, KY USA Univ Kentucky Lexington KY USA pt Microbiol & Immunol, Lexington, KY USA Univ Kentucky, Dept Anat & Neurobiol, Lexington, KY USA Univ Kentucky Lexington KY USA Dept Anat & Neurobiol, Lexington, KY USA Univ Kentucky, Tobacco Hlth Res Inst, Lexington, KY USA Univ Kentucky Lexington KY USA Tobacco Hlth Res Inst, Lexington, KY USA Western Gen Hosp, Edinburgh EH4 2XU, Midlothian, Scotland Western Gen Hosp Edinburgh Midlothian Scotland EH4 2XU dlothian, Scotland
Titolo Testata:
JOURNAL OF PSYCHOPHARMACOLOGY
fascicolo: 3, volume: 14, anno: 2000,
pagine: 222 - 227
SICI:
0269-8811(200009)14:3<222:NADODS>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; CEREBROSPINAL-FLUID; TYPE-1 REPLICATION; HIV-INFECTION; IN-VITRO; EXTRAPYRAMIDAL SYMPTOMS; STRIATAL DOPAMINE; SODIUM VALPROATE; PROTEIN TAT; APOPTOSIS;
Keywords:
AIDS; basal ganglia; brain; cocaine; dementia; dopamine; HIV; methamphetamine; neuroleptics; opiates; Parkinson's disease;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
57
Recensione:
Indirizzi per estratti:
Indirizzo: Nath, A Univ Kentucky, Dept Neurol, Lexington, KY 40506 USA Univ KentuckyLexington KY USA 40506 rol, Lexington, KY 40506 USA
Citazione:
A. Nath et al., "Neurotoxicity and dysfunction of dopaminergic systems associated with AIDSdementia", J PSYCHOPH, 14(3), 2000, pp. 222-227

Abstract

Infection with the human immunodefiency virus (HIV) selectively targets the basal ganglia resulting in loss of dopaminergic neurons. Although frequently asymptomatic, some patients may develop signs of dopamine deficiency denovo, Accordingly, they are highly susceptible to drugs that act on dopaminergic systems. Both neuroleptics and psychostimulants may exacerbate thesesymptoms. Experimental evidence suggests that viral proteins such as gp120and Tat can cause toxicity to dopaminergic neurons, and this toxicity is synergistic with compounds such as methamphetamine and cocaine that also acton the dopaminergic system. In addition, other neurotransmitters that modulate dopaminergic function, such as glutamate and opioids, may also modify the susceptibility of the dopamine system to HIV. Therefore, a thorough understanding of the mechanisms that lead to this selective neurotoxicity of dopaminergic neurons would also likely lead to the development of therapeutic modalities for patients with HIV dementia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/01/20 alle ore 12:28:09