Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
HIV dementia: the role of the basal ganglia and dopaminergic systems
Autore:
Berger, JR; Arendt, G;
Indirizzi:
Univ Kentucky, Coll Med, Dept Neurol, Lexington, KY 40506 USA Univ Kentucky Lexington KY USA 40506 Dept Neurol, Lexington, KY 40506 USA Univ Kentucky, Coll Med, Dept Internal Med, Lexington, KY USA Univ Kentucky Lexington KY USA Med, Dept Internal Med, Lexington, KY USA Univ Dusseldorf, Dept Neurol, D-4000 Dusseldorf, Germany Univ Dusseldorf Dusseldorf Germany D-4000 ol, D-4000 Dusseldorf, Germany
Titolo Testata:
JOURNAL OF PSYCHOPHARMACOLOGY
fascicolo: 3, volume: 14, anno: 2000,
pagine: 214 - 221
SICI:
0269-8811(200009)14:3<214:HDTROT>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACQUIRED-IMMUNODEFICIENCY-SYNDROME; IMMUNE-DEFICIENCY-SYNDROME; CENTRAL-NERVOUS-SYSTEM; AIDS-RELATED COMPLEX; CEREBROSPINAL-FLUID; EXTRAPYRAMIDAL SYMPTOMS; MOVEMENT-DISORDERS; INFECTED PATIENTS; POSITIVE PATIENTS; CEREBRAL LESION;
Keywords:
AIDS; basal ganglia; dementia; dopamine; HIV; Parkinsonism; striatum;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
93
Recensione:
Indirizzi per estratti:
Indirizzo: Berger, JR Univ Kentucky, Coll Med, Dept Neurol, Lexington, KY 40506 USA Univ Kentucky Lexington KY USA 40506 , Lexington, KY 40506 USA
Citazione:
J.R. Berger e G. Arendt, "HIV dementia: the role of the basal ganglia and dopaminergic systems", J PSYCHOPH, 14(3), 2000, pp. 214-221

Abstract

The clinical features of human immunodefiency virus (HIV) dementia exhibittitle hallmarks of a subcortical dementia. These features include psychomotor slowing, apathy, bradykinesia and altered posture and gait similar to those observed in advanced Parkinson's disease. The dementia has the hallmarks attributed to subcortical dementia. The exquisite sensitivity of many ofthese patients to dopamine receptor blockade suggested a profound and, perhaps, selective abnormality of striatal dopaminergic systems. Additional investigations, electrophysiological, pathological, virological, metabolic and radiological studies, indicate that the basal ganglia are a major target of HIV infection. In this review, we describe the evidence for involvement of basal ganglia and, in particular, the dopaminergic systems, in HIV dementia. We also suggest novel therapeutic strategies that may be beneficial inthe treatment of this disorder.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 06:25:58