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Titolo:
Preclinical psychopharmacology of AIDS-associated dementia: lessons to be learned from the cognitive psychopharmacology of other dementias
Autore:
Sarter, M; Podell, J;
Indirizzi:
Ohio State Univ, Dept Psychol, Columbus, OH 43210 USA Ohio State Univ Columbus OH USA 43210 ept Psychol, Columbus, OH 43210 USA Ohio State Univ, Dept Vet Clin Sci, Columbus, OH USA Ohio State Univ Columbus OH USA niv, Dept Vet Clin Sci, Columbus, OH USA
Titolo Testata:
JOURNAL OF PSYCHOPHARMACOLOGY
fascicolo: 3, volume: 14, anno: 2000,
pagine: 197 - 204
SICI:
0269-8811(200009)14:3<197:PPOADL>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; CROSSMODAL DIVIDED ATTENTION; NMDA RECEPTOR ANTAGONIST; ENVELOPE PROTEIN GP120; POSITIVE FIBER DENSITY; CENTRAL-NERVOUS-SYSTEM; HIV-INFECTED PATIENTS; BASAL FOREBRAIN; CORTICAL ACETYLCHOLINE; CHOLINERGIC NEURONS;
Keywords:
AIDS-associated dementia; animal models; cognitive psychopharmacology; senile dementia;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
118
Recensione:
Indirizzi per estratti:
Indirizzo: Sarter, M Ohio State Univ, Dept Psychol, Columbus, OH 43210 USA Ohio StateUniv Columbus OH USA 43210 l, Columbus, OH 43210 USA
Citazione:
M. Sarter e J. Podell, "Preclinical psychopharmacology of AIDS-associated dementia: lessons to be learned from the cognitive psychopharmacology of other dementias", J PSYCHOPH, 14(3), 2000, pp. 197-204

Abstract

Following a brief discussion of the epidemiology, underlying neuropathological mechanisms, neuropsychological symptoms and present treatment strategies of AIDS-associated dementia (AAD), parallels are drawn between the longer standing research on drugs for the treatment of other cognitive disorders, particularly senile dementia, and ongoing efforts to develop psychopharmacological approaches for the treatment of the cognitive impairments in AAD. Important aspects of hypotheses designed to guide such a research are indicated with the help of a speculative, paradigmatic hypothesis concerning the role of cortical cholinergic inputs in AAD. Furthermore, aspects of validity of animal models, and cognition as a crucial intervening variable in the effects of potential treatments, are evaluated.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/01/20 alle ore 15:26:17