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Titolo:
Mechanism of nasal tolerance induced by a recombinant fragment of acetylcholine receptor for treatment of experimental myasthenia gravis
Autore:
Im, SH; Barchan, D; Fuchs, S; Souroujon, MC;
Indirizzi:
Weizmann Inst Sci, Dept Immunol, IL-76100 Rehovot, Israel Weizmann Inst Sci Rehovot Israel IL-76100 unol, IL-76100 Rehovot, Israel Open Univ, IL-61392 Tel Aviv, Israel Open Univ Tel Aviv Israel IL-61392Open Univ, IL-61392 Tel Aviv, Israel
Titolo Testata:
JOURNAL OF NEUROIMMUNOLOGY
fascicolo: 1-2, volume: 111, anno: 2000,
pagine: 161 - 168
SICI:
0165-5728(20001101)111:1-2<161:MONTIB>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
COLLAGEN-INDUCED ARTHRITIS; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; GAMMA IFN-GAMMA; INTERFERON-GAMMA; ORAL TOLERANCE; MESSENGER-RNA; COSTIMULATORY MOLECULES; IMMUNE-RESPONSE; II COLLAGEN; CD40 LIGAND;
Keywords:
experimental autoimmune myasthenia gravis; nasal tolerance; immunotherapy; Th1/Th2; costimulatory molecules;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Fuchs, S Weizmann Inst Sci, Dept Immunol, IL-76100 Rehovot, Israel Weizmann Inst Sci Rehovot Israel IL-76100 76100 Rehovot, Israel
Citazione:
S.H. Im et al., "Mechanism of nasal tolerance induced by a recombinant fragment of acetylcholine receptor for treatment of experimental myasthenia gravis", J NEUROIMM, 111(1-2), 2000, pp. 161-168

Abstract

Acetylcholine receptor (AChR) is the major autoantigen in myasthenia gravis (MG) and experimental autoimmune MG (EAMG). Here we analyze the mechanisms involved in suppression of ongoing EAMG in rats by nasal administration of a recombinant fragment from the human AChR alpha -subunit. We demonstratethat such a fragment, expressed without a fusion partner, confers nasal tolerance that can be adoptively transferred. Our observations suggest that the underlying mechanism of this nasal tolerance is active suppression involving a shift from a Th1 to a Th2/Th3-regulated AChR-specific response whichmay be mediated by down regulation of costimulatory factors. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 05:00:55