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Titolo:
Dermal microvascular endothelial cells express the 180-kDa macrophage mannose receptor in situ and in vitro
Autore:
Groger, M; Holnthoner, W; Maurer, D; Lechleitner, S; Wolff, K; Mayr, BB; Lobitz, W; Petzelbauer, P;
Indirizzi:
Univ Vienna, Sch Med, Div Gen Dermatol, Dept Dermatol, A-1090 Vienna, Austria Univ Vienna Vienna Austria A-1090 Dept Dermatol, A-1090 Vienna, Austria Univ Vienna, Div Allergy Immunol & Infect Dis, Dept Dermatol, A-1090 Vienna, Austria Univ Vienna Vienna Austria A-1090 Dept Dermatol, A-1090 Vienna, Austria Univ Vienna, Inst Microbiol & Genet, A-1090 Vienna, Austria Univ Vienna Vienna Austria A-1090 robiol & Genet, A-1090 Vienna, Austria
Titolo Testata:
JOURNAL OF IMMUNOLOGY
fascicolo: 10, volume: 165, anno: 2000,
pagine: 5428 - 5434
SICI:
0022-1767(20001115)165:10<5428:DMECET>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
MYCOBACTERIAL PHAGOSOME MATURATION; IMMUNE-COMPLEXES; DENDRITIC CELLS; FC-RECEPTORS; EARLY ENDOSOMES; IFN-GAMMA; T-CELLS; IN-SITU; ENDOCYTOSIS; ACTIVATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Petzelbauer, P Univ Vienna, Sch Med, Div Gen Dermatol, Dept Dermatol, Waehringer Guertel 18-20, A-1090 Vienna, Austria Univ Vienna Waehringer Guertel18-20 Vienna Austria A-1090
Citazione:
M. Groger et al., "Dermal microvascular endothelial cells express the 180-kDa macrophage mannose receptor in situ and in vitro", J IMMUNOL, 165(10), 2000, pp. 5428-5434

Abstract

Expression of the 180-kDa mannose receptor (MR) is mainly found on cells of the macrophage lineage. MR mediates the uptake of micro-organisms and host-derived glycoproteins. We demonstrate that endothelium of the human skin in situ and dermal microvascular endothelial cells (DMEC) in vitro expressed MR at both the protein and mRNA levels, In contrast, HUVEC were consistently negative for MR expression, DMEC internalized dextran as well as Escherichia coli by the may of MR into acidic phagosomes, only a few of which fused with CD63- and lysosomal-associated membrane glycoprotein-2-positive lysosomes, This contrasts with the situation in monocyte-derived dendritic cells, where almost all of the MR-Ag complexes reached CD63- and lysosomal-associated membrane glycoprotein-2-positive compartments, indicating differences in the phagolysosomal fusion rate between DMEC and dendritic cells. In conclusion, DMEC express functional MR, a finding that corroborates a role of skin endothelium in Ag capture/clearing.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 12:55:03