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Titolo:
Transplant vasculopathy: Viral anti-inflammatory serpin regulation of atherogenesis
Autore:
Lucas, A; Dai, EB; Liu, LY; Guan, HY; Nash, P; McFadden, G; Miller, L;
Indirizzi:
Univ Western Ontario, John P Robarts Res Inst, Vasc Biol Grp, London, ON N6G 5K8, Canada Univ Western Ontario London ON Canada N6G 5K8 London, ON N6G 5K8, Canada Univ Minnesota, Div Cardiol, Minneapolis, MN USA Univ Minnesota Minneapolis MN USA sota, Div Cardiol, Minneapolis, MN USA Univ Western Ontario, Dept Microbiol & Immunol, London, ON, Canada Univ Western Ontario London ON Canada biol & Immunol, London, ON, Canada
Titolo Testata:
JOURNAL OF HEART AND LUNG TRANSPLANTATION
fascicolo: 11, volume: 19, anno: 2000,
pagine: 1029 - 1038
SICI:
1053-2498(200011)19:11<1029:TVVASR>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLASMINOGEN-ACTIVATOR INHIBITOR-1; CORONARY-ARTERY DISEASE; NEOINTIMA FORMATION; REJECTION; EXPRESSION; RESTENOSIS; UROKINASE; ATHEROSCLEROSIS; RECEPTOR; INJURY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Lucas, A Univ Western Ontario, John P Robarts Res Inst, Vasc Biol Grp, 100Perth Dr,POB 5015, London, ON N6G 5K8, Canada Univ Western Ontario 100 Perth Dr,POB 5015 London ON Canada N6G 5K8
Citazione:
A. Lucas et al., "Transplant vasculopathy: Viral anti-inflammatory serpin regulation of atherogenesis", J HEART LUN, 19(11), 2000, pp. 1029-1038

Abstract

Background: Surgical and ischemic injury to the artery wall initiates vascular wound-healing responses that stimulate atherosclerotic plaque growth. The plasminogen activators have cellular chemotactic, adhesion, and proteolytic activity. Serp-1 is a secreted myxoma virus glycoprotein serpin that binds and inhibits plasminogen activators. We have examined the effects of Serp-1 on plaque growth and inflammatory cell invasion in animal models after balloon injury and after aortic allograft transplant. Methods: We used histologic analysis to assess 4 animal models of angioplasty-mediated injury and 2 models of aortic allograft transplant fur intimalhyperplasia and cellular invasion. We assessed plasminogen activator (uPA and tPA) and inhibitor (PAI-1) expression in rat iliofemoral arteries afterballoon injury using Western blot, enzyme activity, and quantitative reverse transcriptase-polymerase chain reaction (RT-PCR). Results: Plaque growth after balloon injury decreased after Serp-1 treatment in all balloon-injury models tested. Transplant vasculopathy also significantly decreased in 2 rat models of aortic allograft transplant. Infusion of a Serp-1 active site mutant, that lacked plasminogen activator inhibiting activity, did not inhibit plaque growth. Quantitative RT-PCR detected increased transcription of PAI-1 mRNA. Increased PAI-1 protein and enzyme-inhibitory activity was also detected in Serp-1-treated arteries by activity assay and Western blot. Conclusions: Thrombolytic serpins are central regulatory agents in vascular wound-healing responses. Investigation of the inhibitory mechanisms of viral serpins may provide new insights into atherogenesis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 06:41:33