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Titolo:
Osteonecrosis in HIV: A case-control study
Autore:
Scribner, AN; Troia-Cancio, PV; Cox, BA; Marcantonio, D; Hamid, F; Keiser, P; Levi, M; Allen, B; Murphy, K; Jones, RE; Skiest, DJ;
Indirizzi:
Univ Texas, SW Med Ctr, Div Infect Dis, Dallas, TX 75390 USA Univ Texas Dallas TX USA 75390 Ctr, Div Infect Dis, Dallas, TX 75390 USA Univ Texas, Dept Med, Dallas, TX 75230 USA Univ Texas Dallas TX USA 75230Univ Texas, Dept Med, Dallas, TX 75230 USA Univ Texas, Dept Radiol, Dallas, TX 75230 USA Univ Texas Dallas TX USA 75230 v Texas, Dept Radiol, Dallas, TX 75230 USA Univ Texas, Dept Orthoped Surg, Dallas, TX 75230 USA Univ Texas Dallas TXUSA 75230 , Dept Orthoped Surg, Dallas, TX 75230 USA St Paul Med Ctr, ID Associates, Dallas, TX USA St Paul Med Ctr Dallas TX USA aul Med Ctr, ID Associates, Dallas, TX USA Aesculapius Med Hlth Grp, Dallas, TX USA Aesculapius Med Hlth Grp Dallas TX USA pius Med Hlth Grp, Dallas, TX USA Sierra Infect Dis, Reno, NV USA Sierra Infect Dis Reno NV USASierra Infect Dis, Reno, NV USA
Titolo Testata:
JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
fascicolo: 1, volume: 25, anno: 2000,
pagine: 19 - 25
SICI:
1525-4135(20000901)25:1<19:OIHACS>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMMUNODEFICIENCY-VIRUS INFECTION; PROTEIN-S DEFICIENCY; AVASCULAR NECROSIS; MEGESTROL-ACETATE; ANTICARDIOLIPIN ANTIBODIES; FEMORAL-HEAD; PATIENT; BONE; AIDS;
Keywords:
avascular necrosis; osteonecrosis; AIDS; HIV; protease inhibitors;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Skiest, DJ Univ Texas, SW Med Ctr, Div Infect Dis, 5323 Harry Hines Blvd, Dallas, TX 75390 USA Univ Texas 5323 Harry Hines Blvd Dallas TX USA 75390 75390 USA
Citazione:
A.N. Scribner et al., "Osteonecrosis in HIV: A case-control study", J ACQ IMM D, 25(1), 2000, pp. 19-25

Abstract

Background: Osteonecrosis (avascular necrosis) has been infrequently reported in HIV-infected patients. It is not known whether HIV itself is an independent risk factor for osteonecrosis. Methods: We identified 25 patients with osteonecrosis from 1984 to 1999 from a large county teaching hospital and two large practices in Dallas County that specialize in HIV-disease related therapy. A retrospective chart review was performed to evaluate potential risk factors for osteonecrosis. Each case was matched with two controls for HIV positive status and date of osteonecrosis diagnosis. Results: In the study, 22 of 25 (88%) case patients had at least one osteonecrosis risk factor compared with 24 of 50 (48%) controls, p = .003. The most common osteonecrosis risk factors were hyperlipidemia (32%), alcoholism(28%), pancreatitis (16%), corticosteroids (12%), and hypercoaguability (12%). Of the cases, 12% were idiopathic. Multiple joints were involved in 72% of cases. Four of the case patients compared with none of the controls received megesterol acetate before the diagnosis of osteonecrosis, p = .01. No significant differences were found between cases and controls with respect to liver function tests, testosterone levels, triglyceride levels, cholesterol levels, or CD4 cell counts. Saquinavir was independently associated with osteonecrosis, p < .05, However, no differences in overall use of protease inhibitors among cases and controls were noted: 79% versus 76%, respectively. Conclusions: The increased incidence of osteonecrosis in HIV/AIDS may be due to an increased frequency of risk factors previously associated with osteonecrosis such as hyperlipidemia, corticosteroid use, alcohol abuse, and hypercoaguability. Use of protease inhibitors was not independently associated with osteonecrosis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 19:14:28