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Titolo:
Adipose-derived stromal cells - their utility and potential in bone formation
Autore:
Halvorsen, YC; Wilkison, WO; Gimble, JM;
Indirizzi:
Zen Bio Inc, Res Triangle Pk, NC 27709 USA Zen Bio Inc Res Triangle Pk NCUSA 27709 c, Res Triangle Pk, NC 27709 USA
Titolo Testata:
INTERNATIONAL JOURNAL OF OBESITY
, volume: 24, anno: 2000, supplemento:, 4
pagine: S41 - S44
SICI:
0307-0565(200011)24:<S41:ASC-TU>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
MESENCHYMAL STEM-CELLS; OSTEOBLAST DIFFERENTIATION; ADIPOCYTES; PRECURSORS; GENE;
Keywords:
human adipocytes; stromal cells; differentiation; tissue engineering;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Halvorsen, YC Zen Bio Inc, 3200 Chapel Hill Nelson Blvd, Res Triangle Pk, NC 27709 USA Zen Bio Inc 3200 Chapel Hill Nelson Blvd Res Triangle Pk NC USA 27709
Citazione:
Y.C. Halvorsen et al., "Adipose-derived stromal cells - their utility and potential in bone formation", INT J OBES, 24, 2000, pp. S41-S44

Abstract

Many organs contain connective tissue or stromal cells and these cells play important roles in growth, development and tissue repair. Subcutaneous adipose tissue represents an accessible reservoir for the isolation of human stromal cells. Ex vivo, the adipose tissue-derived human stromal cells can be expanded more than 100-fold. These primary cultures respond to adipogenic agonists by accumulating lipid and expressing adipocyte specific proteins, including leptin and the peroxisome proliferator-activated receptor gamma(PPAR gamma), In contrast, when the adipose tissue-derived stromal cells are exposed to osteogenic factors, they display osteoblastic gene markers and mineralize their extracellular matrix. This work demonstrates that subcutaneous adipose tissue is a readily available source of multipotential stromal cells. It is possible that these cells will be used clinically to treat a broad range of orthopedic, rheumatologic and periodontal disorders.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 19:38:33