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Titolo:
COMBINATORIAL SIGNALING BY TWISTED GASTRULATION AND DECAPENTAPLEGIC
Autore:
MASON ED; WILLIAMS S; GROTENDORST GR; MARSH JL;
Indirizzi:
UNIV CALIF IRVINE,CTR DEV BIOL IRVINE CA 92697 UNIV CALIF IRVINE,CTR DEV BIOL IRVINE CA 92697 UNIV CALIF IRVINE,DEPT DEV & CELL BIOL IRVINE CA 92697 UNIV MIAMI,SCH MED,DEPT CELL BIOL & ANAT MIAMI FL 33101
Titolo Testata:
Mechanisms of development
fascicolo: 1-2, volume: 64, anno: 1997,
pagine: 61 - 75
SICI:
0925-4773(1997)64:1-2<61:CSBTGA>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
TISSUE GROWTH-FACTOR; EARLY DROSOPHILA EMBRYOS; DORSAL-VENTRAL PATTERN; IMMEDIATE EARLY GENE; HEAT-SHOCK; DEVELOPMENTAL REGULATION; MESODERM INDUCTION; WINGLESS PROTEIN; CELL-SURFACE; EXPRESSION;
Keywords:
SECRETED PROTEIN; DORSAL VENTRAL PATTERNING; TWISTED GASTRULATION; DECAPENTAPLEGIC; COMBINATORIAL SIGNALING; PERMISSIVE INDUCTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
62
Recensione:
Indirizzi per estratti:
Citazione:
E.D. Mason et al., "COMBINATORIAL SIGNALING BY TWISTED GASTRULATION AND DECAPENTAPLEGIC", Mechanisms of development, 64(1-2), 1997, pp. 61-75

Abstract

The Twisted Gastrulation (TSG) protein is one of five secreted proteins required to pattern the dorsal part of the early Drosophila embryo. Unlike the Decapentaplegic (DPP) protein that is required to pattern the entire dorsal half of the embryo, TSG is needed only to specify the fate of the dorsal midline cells. Here we have misexpressed the tsg gene with different promoters to address its mechanism of action and relationship to DPP. When expressed in a ventral stripe of cells, TSG protein can diffuse to the dorsalmost cells and can rescue the dorsal midline cells in tsg mutant embryos. Despite elevated levels that exceed those needed for biological activity, there was no change in dorsal midline or lateral cell fates under any conditions tested. We concludethat TSG does not modulate an activity gradient of DPP. Instead, it functions in a permissive rather than instructive role to elaborate cell fates along the dorsal midline after peak levels of DPP activity have 'primed' cells to respond to TSG. The interaction between TSG and DPP defines a novel type of combinatorial synergism. (C) 1997 Elsevier Science Ireland Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 20:51:16