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Titolo:
Cyclin D1 expression in high-grade endometrial carcinomas - Association with histologic subtype
Autore:
Soslow, RA; Shen, PUF; Chung, MH; Isacson, C; Baergen, RN;
Indirizzi:
Cornell Univ, NYPH, WMC, Dept Pathol, New York, NY 10021 USA Cornell UnivNew York NY USA 10021 C, Dept Pathol, New York, NY 10021 USA
Titolo Testata:
INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY
fascicolo: 4, volume: 19, anno: 2000,
pagine: 329 - 334
SICI:
0277-1691(200010)19:4<329:CDEIHE>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROGESTERONE-RECEPTOR CONTENT; HUMAN BREAST-CANCER; IMMUNOHISTOCHEMICAL EVALUATION; LYMPHOCYTIC LYMPHOMA; UTERINE CARCINOMAS; SEROUS CARCINOMA; PROGNOSTIC VALUE; OVARIAN-TUMORS; ESTROGEN; P53;
Keywords:
endometrium; carcinoma; cyclin D;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Soslow, RA Cornell Univ, NYPH, WMC, Dept Pathol, 525 E 68th St,Starr 1039,New York, NY 10021 USA Cornell Univ 525 E 68th St,Starr 1039 New York NY USA 10021 USA
Citazione:
R.A. Soslow et al., "Cyclin D1 expression in high-grade endometrial carcinomas - Association with histologic subtype", INT J GYN P, 19(4), 2000, pp. 329-334

Abstract

Endometrial endometrioid adenocarcinoma (EC) and serous carcinoma (ESC) are associated with different epidemiologic risk factors, precursor lesions, morphology, and survival outcomes. They also possess distinct molecular profiles. We investigated the expression of cyclin D1, a member of the G1 cyclin family that regulates the G1/S transition in the cell cycle, and estrogen and progesterone receptors (ERs and PRs, respectively) in a group of ECs and ESCs matched for histological grade. We also sought to correlate the expression of cyclin D1 with ER and PR because cyclin D1 has been reported tostimulate transcription of ER- and PR-regulated genes (1,2). We hypothesize that cyclin D1 expression covaries with histologic subtype and is relatedto the expression of ER and PR. Twenty ESCs and 21 ECs were examined histologically and evaluated immunohistochemically for cyclin D1: ER, and PR using commercially available monoclonal antibodies in archival, formalin-fixed, and paraffin-embedded tissue. Three ESCs (15%) and 10 ECs (48%) expressedcyclin D1 (p = 0.02). Twelve ESCs (60%) and 16 ECs (76%) expressed ER, which is not significantly different. ER-positive ECs were significantly more likely to express cyclin D1 compared with ER-positive ESCs (p = 0.03), but a relationship between cyclin D1 and ER expression in EC was not found. We also did not find a significant relationship between cyclin D1 and PR expression. Therefore, cyclin D1 expression in poorly differentiated endometrialcarcinomas is associated with endometrioid histology. This is consistent with pathobiologic divergence in poorly differentiated endometrial carcinomas.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/09/20 alle ore 20:06:27