Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Cyclic core dendrimer as a new kind of vector for gene transfer into mammalian cells
Autore:
Cheng, HH; Zhou, RJ; Liu, L; Du, B; Zhuo, RX;
Indirizzi:
Wuhan Univ, Coll Life Sci, Ctr Dev Biol, Wuhan 430072, Peoples R China Wuhan Univ Wuhan Peoples R China 430072 l, Wuhan 430072, Peoples R China Wuhan Univ, Dept Chem, Minist Educ China, Lab Biomed Polymer Mat, Wuhan 430072, Peoples R China Wuhan Univ Wuhan Peoples R China 430072 t, Wuhan 430072, Peoples R China
Titolo Testata:
GENETICA
fascicolo: 1, volume: 108, anno: 2000,
pagine: 53 - 56
SICI:
0016-6707(2000)108:1<53:CCDAAN>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLYAMIDOAMINE DENDRIMERS; STARBURST; MACROMOLECULES; POLYMERS; COMPLEX; DNA;
Keywords:
dendritic polymer; reporter gene; gene expression; transfection;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
10
Recensione:
Indirizzi per estratti:
Indirizzo: Cheng, HH Wuhan Univ, Coll Life Sci, Ctr Dev Biol, Wuhan 430072, Peoples RChina Wuhan Univ Wuhan Peoples R China 430072 30072, Peoples R China
Citazione:
H.H. Cheng et al., "Cyclic core dendrimer as a new kind of vector for gene transfer into mammalian cells", GENETICA, 108(1), 2000, pp. 53-56

Abstract

Cyclic core dendritic polymer is a new type of synthetic polymers. The ability of generation 4 of the dendrimer with a core of 1,4,7,10-tetraazacyclododecane to function as an effective gene delivery vector was investigated. Results from fluorescence in situ hybridization (FISH) show that the pCH 110 plasmid DNA was transferred into human small intestine cancer metastaticascites (HICMA) cells induced by this kind of dendrimer as a vector. The transferred LacZ, GFP and luciferase genes were highly expressed in the transfected HICMA, COS-7 and 293 cells. These studies demonstrate that the dendrimer can transfect mammalian cells in vitro which offers an alternatively efficient method for mammalian gene transfer.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 07:53:13