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Titolo:
Phylogenetic analysis of teneurin genes and comparison to the rearrangement hot spot elements of E-coli
Autore:
Minet, AD; Chiquet-Ehrismann, R;
Indirizzi:
Friedrich Miescher Inst, CH-4002 Basel, Switzerland Friedrich Miescher Inst Basel Switzerland CH-4002 002 Basel, Switzerland
Titolo Testata:
GENE
fascicolo: 1, volume: 257, anno: 2000,
pagine: 87 - 97
SICI:
0378-1119(20001017)257:1<87:PAOTGA>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
PAIR-RULE GENE; ODD-OZ ODZ; ESCHERICHIA-COLI; RHS ELEMENTS; FAMILY; EXPRESSION; PROTEINS; COMPOSITES; NEURESTIN; TENASCIN;
Keywords:
carbohydrate binding; DOC4; horizontal gene transfer; nervous system; neurestin; odz; ten-a; ten-m; transmembrane protein; XLMR/MRX;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Chiquet-Ehrismann, R Friedrich Miescher Inst, Maulbeerstr 66, CH-4058 Basel, Switzerland Friedrich Miescher Inst Maulbeerstr 66 Basel Switzerland CH-4058
Citazione:
A.D. Minet e R. Chiquet-Ehrismann, "Phylogenetic analysis of teneurin genes and comparison to the rearrangement hot spot elements of E-coli", GENE, 257(1), 2000, pp. 87-97

Abstract

Teneurins are a novel family of transmembrane proteins conserved between invertebrates and vertebrates. There are two members in Drosophila, one in C. elegans and four members in mouse. Here, we describe the analysis of the genomic structure of the human teneurin-1 gene. The entire human teneurin-1(TEN1) gene is contained in eight PAC clones representing part of the chromosomal locus Xq25. Interestingly, many X-linked mental retardation syndromes (XLMR) and non-specific mental retardation (MRX) are mapped to this region. The location of the human TEN1 together with the neuronal expression makes TEN1 a candidate gene for XLMR and MRX. We also identified large parts of the human teneurin-2 sequence on chromosome 5 and sections of human teneurin-4 at chromosomal position 11q14. Database searches resulted in the identification of ESTs encoding parts of all four human members of the teneurin family. Analysis of the genomic organization of the Drosophila ten-a generevealed the presence of exons encoding a long form of ten-a, which can bealigned with all other teneurins known. Sequence comparison and phylogenetic trees of teneurins show that insects and vertebrates diverged before theteneurin ancestor was duplicated independently in the two phyla. This is supported by the presence of conserved intron positions between teneurin genes of man, Drosophila and C. elegans. It is therefore not possible to classany of the vertebrate teneurins with either Drosophila Ten-a or Ten-m. TheC-terminal part of all teneurins harbours 26 repetitive sequence motifs termed YD-repeats. YD-repeats are most similar to the repeats encoded by the core of the rearrangement hot spot (rhs) elements of Escherichia coli. Thismakes the teneurin ancestor a candidate gene for the source of the rhs core acquired by horizontal gene transfer. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 03:16:16