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Titolo:
Activation-induced T cell death occurs at G1A phase of the cell cycle
Autore:
Li, QS; Tanaka, S; Kisenge, RR; Toyoda, H; Azuma, E; Komada, Y;
Indirizzi:
Mie Univ, Sch Med, Dept Pediat, Tsu, Mie 5148507, Japan Mie Univ Tsu Mie Japan 5148507 Med, Dept Pediat, Tsu, Mie 5148507, Japan Natl Mie Chuo Hosp, Dept Pediat, Tsu, Mie, Japan Natl Mie Chuo Hosp Tsu Mie Japan Chuo Hosp, Dept Pediat, Tsu, Mie, Japan Mie Univ, Sch Med, Dept Clin Immunol, Tsu, Mie 514, Japan Mie Univ Tsu Mie Japan 514 ch Med, Dept Clin Immunol, Tsu, Mie 514, Japan
Titolo Testata:
EUROPEAN JOURNAL OF IMMUNOLOGY
fascicolo: 11, volume: 30, anno: 2000,
pagine: 3329 - 3337
SICI:
0014-2980(200011)30:11<3329:ATCDOA>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
FAS-MEDIATED APOPTOSIS; SURFACE PHENOTYPE; LYMPHOCYTES-T; S-PHASE; IN-VIVO; PROLIFERATION; RECEPTOR; PROTEIN; GROWTH; INTERLEUKIN-2;
Keywords:
T cell; activation-induced cell death; caspase-3; cell cycle regulation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Komada, Y Mie Univ, Sch Med, Dept Pediat, 2-174 Edobashi, Tsu, Mie 5148507, Japan Mie Univ 2-174 Edobashi Tsu Mie Japan 5148507 Mie 5148507, Japan
Citazione:
Q.S. Li et al., "Activation-induced T cell death occurs at G1A phase of the cell cycle", EUR J IMMUN, 30(11), 2000, pp. 3329-3337

Abstract

Peripheral negative selection of cycling T cells after TCR engagement and deletion of activated T cells after an immune response occur by an apoptotic process termed activation-induced cell death (AICD). The cross-linking ofTCR-CD3 complex with anti-CD3 monoclonal antibody led to significant apoptotic cell death in peripheral blood T cells. To further define cell cycle restriction points for triggering AICD in T cells, we evaluated the association between cell cycle progression and death signal transduction. Simultaneous DNA/RNA quantification analysis revealed that T cells entering G1A phase of the cell cycle may acquire sensitivity to AICD. The activation of caspase-3 was induced when T cells entered G1A phase. Up-regulation of cyclin-dependent kinases (Cdk4 and Cdk6) and cyclin D3 was initiated in TOP-stimulated T cells entering G1A phase and expression of these markers steadily increased as T cells progressed from G1A into G1B phase. Interestingly, caspase-3 inhibitors could inhibit the up-regulation of these G1 cell cycle regulators and induce G0/G1A arrest as well as the inhibition of AICD. On the basis of these results, AICD signals are most likely transduced into TCR-stimulated T cells entering G1A phase. T cells that fail to progress from G1A into G1B phase undergo AICD.

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Documento generato il 10/04/20 alle ore 02:10:37