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Titolo:
Total occlusion trial with angioplasty by using laser guidewire - The total trial
Autore:
Serruys, PW; Hamburger, JN; Koolen, JJ; Fajadet, J; Haude, M; Klues, H; Seabra-Gomes, R; Corcos, T; Hamm, C; Pizzuli, L; Meier, B; Mathey, D; Fleck, E; Taeymans, Y; Melkert, R; Teunissen, Y; Simon, R;
Indirizzi:
Univ Rotterdam Hosp, Ctr Heart, Dept Intervent Cardiol, Rotterdam, Netherlands Univ Rotterdam Hosp Rotterdam Netherlands rdiol, Rotterdam, Netherlands
Titolo Testata:
EUROPEAN HEART JOURNAL
fascicolo: 21, volume: 21, anno: 2000,
pagine: 1797 - 1805
SICI:
0195-668X(200011)21:21<1797:TOTWAB>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY-ARTERY OCCLUSION; SHORT-TERM; RECANALIZATION; BALLOON; PTCA; WIRE;
Keywords:
chronic total coronary occlusion; randomized trial; laser angioplasty;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Serruys, PW Erasmus Univ, Ctr Heart, Dept Intervent Cardiol, Bd 412,POB 1738, NL-3000 DR Rotterdam, Netherlands Erasmus Univ Bd 412,POB 1738 Rotterdam Netherlands NL-3000 DR
Citazione:
P.W. Serruys et al., "Total occlusion trial with angioplasty by using laser guidewire - The total trial", EUR HEART J, 21(21), 2000, pp. 1797-1805

Abstract

Aims A randomized trial was performed to assess the safety and efficacy ofa laser guidewire, in the treatment of chronic coronary occlusions. Methods and Results In 18 European centres, 303 patients with a chronic coronary occlusion were randomized to treatment with either the laser guidewire (n=144) or conventional guidewires (mechanical guidewire, n=159). The primary end-point of the study was treatment success, defined as reaching thetrue lumen distal to the occlusion by the allocated wire within 30 min of fluoroscopic time: laser guidewire vs mechanical guidewire; 52.8% (n=76) vs47.2% (n=75), P=0.33. Serious adverse events following the initial guidewire attempt were 0% (laser guidewire) and 0.6% (mechanical guidewire), respectively. Angioplasty (performed following successful guidewire crossing) was successful in 179 patients (91%, laser guidewire n=79, mechanical guidewire n=100), followed by stent implantation in 149 (79%). At the 6-month angiographic follow-up, the difference in binary restenosis rate (laser guidewire vs mechanical guidewire; 45.5% vs 38.3%, P=0.72) or reocclusion rate (25.8% vs 16.1%, P=0.15) did not reach statistical significance. At 1, 6 and 12 months, angina and event-free survival were 69%, 35% and 24% (laser guidewire) vs 74%, 40% and 31% (mechanical guidewire). Conclusion Although laser guidewire technology was safe, the increase in crossing success did not reach statistical significance. (Eur Heart J 2000; 21: 1797-1805, doi:10,1053/enhj,2000, 2263) (C) 2000 The European Society of Cardiology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 11:26:54