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Titolo:
Ketamine controls prolonged status epilepticus
Autore:
Borris, DJ; Bertram, EH; Kapur, J;
Indirizzi:
Univ Virginia, Hlth Sci Ctr, Dept Neurol, Charlottesville, VA 22903 USA Univ Virginia Charlottesville VA USA 22903 Charlottesville, VA 22903 USA
Titolo Testata:
EPILEPSY RESEARCH
fascicolo: 2-3, volume: 42, anno: 2000,
pagine: 117 - 122
SICI:
0920-1211(200012)42:2-3<117:KCPSE>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUSTAINING STATUS EPILEPTICUS; CONVULSIVE STATUS EPILEPTICUS; LIMBIC STATUS EPILEPTICUS; NMDA RECEPTOR ANTAGONIST; NEURONAL DAMAGE; MK-801; DIAZEPAM;
Keywords:
phenobarbital; ketamine; refractory seizure;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Kapur, J Univ Virginia, Hlth Sci Ctr, Dept Neurol, Box 800394, Charlottesville, VA 22903 USA Univ Virginia Box 800394 Charlottesville VA USA 22903 A 22903 USA
Citazione:
D.J. Borris et al., "Ketamine controls prolonged status epilepticus", EPILEPSY R, 42(2-3), 2000, pp. 117-122

Abstract

New treatments are needed to control prolonged status epilepticus given the high failure rate of current therapies. In an animal model of status epilepticus based on electrical stimulation of the hippocampus, rats demonstrate at least 5 five-hours of seizure activity following stimulation. Phenobarbital (70 mg/kg) administered 15 min after stimulation effectively controlled seizures in 66% of animals (n = 6). When phenobarbital (70 mg/kg) was administered 60 min after stimulation, seizures were controlled in 25% of animals (n=4). Ketamine (100 mg/kg) administered 15 min after stimulation did not control seizures in any animal (n = 4). But when ketamine was administered one hour after stimulation it effectively controlled seizures in all animals (n = 4). Increasing doses of ketamine were administered 60 min after stimulation to generate a dose-response curve. The ketamine dose response (fraction of seizure free rats) data were fit to a sigmoid curve to derive an ED50 of 58 mg/kg. These findings suggest that prolonged status epilepticus becomes refractory to phenobarbital but can be effectively controlled by ketamine. For patients experiencing prolonged status epilepticus that is refractory to phenobarbital, ketamine may be an alternative to general anesthesia. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/01/20 alle ore 19:07:42