Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Distribution of particulate matter and tissue remodeling in the human lung
Autore:
Pinkerton, KE; Green, FHY; Saiki, C; Vallyathan, V; Plopper, CG; Gopal, V; Hung, D; Bahne, EB; Lin, SS; Menache, MG; Schenker, MB;
Indirizzi:
Univ Calif Davis, Dept Anat Physiol & Cell Biol, Sch Vet Med, Davis, CA 95616 USA Univ Calif Davis Davis CA USA 95616 iol, Sch Vet Med, Davis, CA 95616 USA Univ Calif Davis, Dept Epidemiol & Prevent Med, Sch Med, Davis, CA 95616 USA Univ Calif Davis Davis CA USA 95616 ent Med, Sch Med, Davis, CA 95616 USA Univ Calgary, Dept Pathol & Lab Med, Fac Med, Calgary, AB T2N 1N4, Canada Univ Calgary Calgary AB Canada T2N 1N4 c Med, Calgary, AB T2N 1N4, Canada NIOSH, Morgantown, WV USA NIOSH Morgantown WV USANIOSH, Morgantown, WV USA Fresno Med Coroners Off, Fresno, CA USA Fresno Med Coroners Off Fresno CAUSA o Med Coroners Off, Fresno, CA USA Univ New Mexico, Sch Med, Dept Pediat, Albuquerque, NM 87131 USA Univ New Mexico Albuquerque NM USA 87131 ediat, Albuquerque, NM 87131 USA
Titolo Testata:
ENVIRONMENTAL HEALTH PERSPECTIVES
fascicolo: 11, volume: 108, anno: 2000,
pagine: 1063 - 1069
SICI:
0091-6765(200011)108:11<1063:DOPMAT>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
SAN-JOAQUIN VALLEY; SMALL AIRWAYS; CIGARETTE-SMOKING; DISEASES; PNEUMOCONIOSIS; POPULATION; PARENCHYMA; PARTICLES; EXPOSURE;
Keywords:
asthma; California; fibrosis; lung pathology; PM2.5; PM10; particulate matter; pigmentation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Pinkerton, KE Univ Calif Davis, Dept Anat Physiol & Cell Biol, Sch Vet Med, 1321 Haring Hall, Davis, CA 95616 USA Univ Calif Davis 1321 Haring Hall Davis CA USA 95616 616 USA
Citazione:
K.E. Pinkerton et al., "Distribution of particulate matter and tissue remodeling in the human lung", ENVIR H PER, 108(11), 2000, pp. 1063-1069

Abstract

We examined the relationship between intrapulmonary particle distribution of carbonaceous and mineral dusts and remodeling of the airways along anatomically distinct airway paths in the lungs of Hispanic males from the central valley of California. Lung autopsy specimens from the Fresno County Coroner's Office were prepared by intratracheal instillation of 2% glutaraldehyde at 30 cm H2O pressure. Two distinct airway paths into the apico-posterior and apico-anterior portions of the left upper lung lobe were followed. Tissue samples for histologic analysis were generally taken from the intrapulmonary second, fourth, sixth, and ninth airway generations. Parenchymal tissues beyond the 12th airway generation of each airway path were also analyzed. There was little evidence of visible particle accumulation in the larger conducting airways (generations 2-6), except in bronchial-associated lymphoid tissues and within peribronchial connective tissue. In contrast, terminal and respiratory bronchioles arising from each pathway revealed varying degrees of wall thickening and remodeling. Walls with marked thickening contained moderate to heavy amounts of carbonaceous and mineral dusts. Wall thickening was associated with increases in collagen and interstitial inflammatory cells, including dust-laden macrophages. These changes were significantly greater in first-generation respiratory bronchioles compared to second- and third-generation respiratory bronchioles. These findings suggest thataccumulation of carbonaceous and mineral dust in the lungs is significantly affected by lung anatomy with the greatest retention in centers of lung acini. Furthermore, there is significant remodeling of this transitional zone in humans exposed to ambient particulate matter.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 11:25:55