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Titolo:
Hormonal control of gubernaculum development during testis descent: Gubernaculum outgrowth in vitro requires both insulin-like factor and androgen
Autore:
Emmen, JMA; McLuskey, A; Adham, IM; Engel, W; Grootegoed, JA; Brinkmann, AO;
Indirizzi:
Erasmus Univ, Dept Endocrinol & Reprod, NL-3000 DR Rotterdam, Netherlands Erasmus Univ Rotterdam Netherlands NL-3000 DR DR Rotterdam, Netherlands Univ Gottingen, Inst Human Genet, D-3400 Gottingen, Germany Univ Gottingen Gottingen Germany D-3400 Genet, D-3400 Gottingen, Germany
Titolo Testata:
ENDOCRINOLOGY
fascicolo: 12, volume: 141, anno: 2000,
pagine: 4720 - 4727
SICI:
0013-7227(200012)141:12<4720:HCOGDD>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
RELAXIN-LIKE FACTOR; LEY I-L; TESTICULAR DESCENT; UROGENITAL TRACT; TISSUE RECOMBINANTS; RAT GUBERNACULUM; INDUCED GROWTH; FETAL-RAT; PIG FETUS; RECEPTOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Emmen, JMA Erasmus Univ, Dept Endocrinol & Reprod, POB 1738, NL-3000 DR Rotterdam, Netherlands Erasmus Univ POB 1738 Rotterdam Netherlands NL-3000 DR erlands
Citazione:
J.M.A. Emmen et al., "Hormonal control of gubernaculum development during testis descent: Gubernaculum outgrowth in vitro requires both insulin-like factor and androgen", ENDOCRINOL, 141(12), 2000, pp. 4720-4727

Abstract

The gubernaculum connects the gonad to the inguinoscrotal region and is involved in testis descent. It rapidly develops in the male fetus, whereas development in the female fetus is lacking. Possible factors involved in gubernaculum development are androgens, anti-Mullerian hormone (AMH), and insulin-like factor (Insl3). Sexual dimorphism in gubernaculum development correlated with the mitotic activity of cells in the gubernacular bulbs from male and female fetuses. Androgen receptor expression was restricted to the mesenchymal core of the gubernacular bulb, whereas skeletal muscle was defected in its outer layer. In an organ culture system devised to further study gubernaculum development in vitro, morphology of gubernacular explants grown in the presence of testes was comparable with that of gubernacula developed in vivo. Testicular tissue or medium containing R1881, a synthetic androgen, had a growth stimulatory effect on gubernacular explants compared withovarian tissue or basal medium only. Moreover, Amh(-/-), Amh(+/-), and Insl3(+/-) testes stimulated the growth of gubernacular explants to the same extent as control testes. Insl3(-/-) testes, however, did not produce such an activity. This study reveals an essential role for both androgen and Insl3 in the gubernaculum outgrowth during transabdominal testis descent.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 22:58:34