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Titolo:
Idiopathic giant-cell granulomatous hypophysitis - Report of a case with autopsy follow-up
Autore:
Wilson, JD; Jacobs, M; Shuer, L; Atlas, S; Horoupian, DS;
Indirizzi:
Stanford Univ Hosp, Dept Pathol, Div Neuropathol, Stanford, CA 94305 USA Stanford Univ Hosp Stanford CA USA 94305 ropathol, Stanford, CA 94305 USA Stanford Univ Hosp, Dept Med, Stanford, CA 94305 USA Stanford Univ Hosp Stanford CA USA 94305 Dept Med, Stanford, CA 94305 USA Stanford Univ Hosp, Dept Surg, Stanford, CA 94305 USA Stanford Univ Hosp Stanford CA USA 94305 ept Surg, Stanford, CA 94305 USA Stanford Univ Hosp, Dept Radiol, Div Neurosurg, Stanford, CA 94305 USA Stanford Univ Hosp Stanford CA USA 94305 eurosurg, Stanford, CA 94305 USA Stanford Univ Hosp, Div Neuroradiol, Stanford, CA 94305 USA Stanford Univ Hosp Stanford CA USA 94305 roradiol, Stanford, CA 94305 USA
Titolo Testata:
CLINICAL NEUROPATHOLOGY
fascicolo: 6, volume: 19, anno: 2000,
pagine: 300 - 304
SICI:
0722-5091(200011/12)19:6<300:IGGH-R>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Keywords:
granulomatous hypophysitis; idiopathic; giant-cell;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
6
Recensione:
Indirizzi per estratti:
Indirizzo: Horoupian, DS Stanford Univ Hosp, Dept Pathol, Div Neuropathol, Room R-241, Stanford, CA94305 USA Stanford Univ Hosp Room R-241 Stanford CA USA 943054305 USA
Citazione:
J.D. Wilson et al., "Idiopathic giant-cell granulomatous hypophysitis - Report of a case with autopsy follow-up", CLIN NEUR, 19(6), 2000, pp. 300-304

Abstract

Idiopathic granulomatous inflammation of the pituitary gland occurs rarely, and is usually identified as an incidental finding at autopsy. However, it may present during life as a mass lesion that clinically mimics other more common pituitary gland lesions. We report a 54-year-old woman presenting with acute onset diabetes insipidus whose MRI showed a 1.1 cm pituitary mass, with infundibular thickening and meningeal enhancement. Biopsy demonstrated granulomatous hypophysitis with multinucleate histiocytes. Special studies for infectious organisms were negative. The patient's disease progressed following biopsy, causing complete loss of vision in the right eye. This responded to high-dose steroids and local low-dose radiation. She later developed an acute inferior myocardial infarction. Laboratory tests failed to demonstrate an underlying autoimmune process. While recovering from this myocardial infarction, she succumbed to pulmonary embolism. Autopsy revealed moderate residual chronic infundibular inflammation. No evidence of systemic or residual pituitary granulomatous disease was identified. To the best of our knowledge, this is the first case of idiopathic granulomatous hypophysitis initially diagnosed by biopsy to have post-mortem neuropathologic examination.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 01:23:06