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Titolo:
Effects of sildenafil citrate (Viagra) combined with nitrate on the heart
Autore:
Ishikura, F; Beppu, S; Hamada, T; Khandheria, BK; Seward, JB; Nehra, A;
Indirizzi:
Mayo Clin & Mayo Fdn, Div Cardiovasc Dis & Internal Med, Rochester, MN 55905 USA Mayo Clin & Mayo Fdn Rochester MN USA 55905 Med, Rochester, MN 55905 USA Mayo Clin & Mayo Fdn, Dept Urol, Rochester, MN 55905 USA Mayo Clin & Mayo Fdn Rochester MN USA 55905 Urol, Rochester, MN 55905 USA Osaka Univ, Fac Med, Sch Allied Hlth Sci, Osaka 530, Japan Osaka Univ Osaka Japan 530 ac Med, Sch Allied Hlth Sci, Osaka 530, Japan
Titolo Testata:
CIRCULATION
fascicolo: 20, volume: 102, anno: 2000,
pagine: 2516 - 2521
SICI:
0009-7322(20001114)102:20<2516:EOSC(C>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE; PHOSPHODIESTERASE INHIBITOR; ERECTILE DYSFUNCTION; ENDOTHELIAL-CELLS; ORGANIC NITRATE; RELAXING FACTOR; NITROGLYCERIN; RELAXATION; DRUGS;
Keywords:
blood flow; coronary disease; sildenafil citrate;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Khandheria, BK Mayo Clin & Mayo Fdn, Div Cardiovasc Dis & Internal Med, 200 1st St SW, Rochester, MN 55905 USA Mayo Clin & Mayo Fdn 200 1st St SW Rochester MN USA 55905 A
Citazione:
F. Ishikura et al., "Effects of sildenafil citrate (Viagra) combined with nitrate on the heart", CIRCULATION, 102(20), 2000, pp. 2516-2521

Abstract

Background-Sildenafil citrate (Viagra) is indicated for the treatment of erectile dysfunction. Large and sudden decreases in systemic blood pressure were reported in a substantial number of patients taking sildenafil citratecombined with nitroglycerin. We studied the effect of sildenafil citrate on the relationship between changes in systemic blood pressure and coronary blood flow. Methods and Results-Healthy male beagles were used to assess systemic blood pressure, pulmonary arterial pressure, and flow in the left circumflex artery tin which a critical stenosis was established) and left anterior descending coronary artery. After measurement of the hemodynamic variables, 2 mg/kg sildenafil citrate was administered via a nasogastric tube. Hemodynamicchanges were monitored for 1 hour. Subsequently, the acute effect of nitrate combined with sildenafil citrate was studied by the bolus injection of 0.2 mg isosorbide dinitrate before and after sildenafil citrate. Systemic blood and pulmonary arterial pressures and circumflex flow did not change during this study; however, left anterior descending coronary arterial flow increased from 16.0+/-5.8 to 24.6+/-8.7 mL/min 1 hour after administration ofsildenafil citrate. The prolongation of systemic blood pressure decrease and the circumflex flow decrement induced by isosorbide dinitrate after sildenafil citrate were significantly larger and longer than those before sildenafil citrate. Conclusions-Sildenafil citrate had the effect of vasodilation in a normal coronary artery; however, a combined effect with nitrate resulted in large and protracted decreases in systemic blood pressure and coronary blood flowin vessels with critical stenosis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 17:11:05