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Titolo:
Separation of the stereoisomers of racemic fluoroquinolone antibacterial agents on a crown-ether-based chiral HPLC stationary phase
Autore:
Hyun, MH; Han, SC; Jin, JS; Lee, W;
Indirizzi:
Pusan Natl Univ, Dept Chem, Pusan 609735, South Korea Pusan Natl Univ Pusan South Korea 609735 Chem, Pusan 609735, South Korea Pusan Natl Univ, Chem Inst Funct Mat, Pusan 609735, South Korea Pusan NatlUniv Pusan South Korea 609735 Mat, Pusan 609735, South Korea Forea Food & Drug Adm, Dept Drug Evaluat, Eunpyung Ku, Seoul 122704, SouthKorea Forea Food & Drug Adm Seoul South Korea 122704 Seoul 122704, SouthKorea LG Chem Ltd, Taejon 305380, South Korea LG Chem Ltd Taejon South Korea 305380 em Ltd, Taejon 305380, South Korea
Titolo Testata:
CHROMATOGRAPHIA
fascicolo: 7-8, volume: 52, anno: 2000,
pagine: 473 - 476
SICI:
0009-5893(200010)52:7-8<473:SOTSOR>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
LIQUID-CHROMATOGRAPHIC RESOLUTION; LB20304; ACIDS;
Keywords:
column liquid chromatography; enantiomer separation; chiral stationary phase; chiral crown ether; quinolone antibacterial agents;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Physical, Chemical & Earth Sciences
Citazioni:
8
Recensione:
Indirizzi per estratti:
Indirizzo: Hyun, MH Pusan Natl Univ, Dept Chem, Pusan 609735, South Korea Pusan Natl Univ Pusan South Korea 609735 an 609735, South Korea
Citazione:
M.H. Hyun et al., "Separation of the stereoisomers of racemic fluoroquinolone antibacterial agents on a crown-ether-based chiral HPLC stationary phase", CHROMATOGR, 52(7-8), 2000, pp. 473-476

Abstract

A chiral stationary phase derived from (+)-( 18-crown-6)-2,3,11,12-tetracarboxylic acid has been successfully used for the direct separation of the enantiomers of racemic fluoroquinolines containing a primary amino group being investigated as antibacterial agents. The chromatographic resolution behavior was found to depend on the content and the type of acidic and organicmodifiers in the mobile phase and on the column temperature.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 20:56:06