Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Chimeric constructs containing the SH4/Unique domains of cYes can restrictthe ability of Scr(527F) to upregulate heme oxygenase-1 expression efficiently
Autore:
Hoey, JG; Summy, J; Flynn, DC;
Indirizzi:
W Virginia Univ, Ctr Canc, Morgantown, WV 26506 USA W Virginia Univ Morgantown WV USA 26506 tr Canc, Morgantown, WV 26506 USA W Virginia Univ, Dept Microbiol & Immunol, Morgantown, WV 26506 USA W Virginia Univ Morgantown WV USA 26506 Immunol, Morgantown, WV 26506 USA W Virginia Univ, Dept Surg, Morgantown, WV 26506 USA W Virginia Univ Morgantown WV USA 26506 pt Surg, Morgantown, WV 26506 USA
Titolo Testata:
CELLULAR SIGNALLING
fascicolo: 9-10, volume: 12, anno: 2000,
pagine: 691 - 701
SICI:
0898-6568(200010)12:9-10<691:CCCTSD>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT CARDIAC MYOCYTES; ENDOTHELIAL GROWTH-FACTOR; AMINO-TERMINAL DOMAIN; SRC GENE-PRODUCTS; TYROSINE PHOSPHORYLATION; C-SRC; DIFFERENTIAL EXPRESSION; CELLULAR-YES; PROTEIN; FAMILY;
Keywords:
Src; Yes; heme oxygenase-1; SH4; Unique domain;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Flynn, DC W Virginia Univ, Ctr Canc, 2822 MBR, Morgantown, WV 26506 USA W Virginia Univ 2822 MBR Morgantown WV USA 26506 n, WV 26506 USA
Citazione:
J.G. Hoey et al., "Chimeric constructs containing the SH4/Unique domains of cYes can restrictthe ability of Scr(527F) to upregulate heme oxygenase-1 expression efficiently", CELL SIGNAL, 12(9-10), 2000, pp. 691-701

Abstract

cSrc and cYes are the two most homologous members of the Src-family of nonreceptor tyrosine kinases. These kinases perform redundant signalling functions in cells; however, there is also evidence to support specificity in signalling. In this report, specificity in signalling between activated formsof the cSrc and cYes oncoproteins was examined at the level of downstream gene expression. Here, pp60C-src(527F) (Src(527F)) and chimeric constructs of Src(527F) containing combinations of the SH4/Unique/SH3/SH2 domains of cYes were generated to determine whether the individual modular domains of cSrc or cYes could direct distinct cellular signals leading to differential gene expression. A biased, differential display analysis approach was used to analyse changes in gene expression. The data indicate that Src(527F) is capable of upregulating heme oxygenase-1 (HO-1) in CEF cells at the level of transcription and protein expression. Chimeric constructs containing the SH4/Unique domains of cYes were less efficient in upregulating HO-1 expression. Activation of cSrc and expression of the HO-1 gene product are each induced under conditions of hypoxia. We hypothesize that activated cSrc can direct upregulation of HO-1 while activated cYes may be less efficient in stimulating signal transduction pathways that direct expression of HO-1. (C) 2000 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 15:10:15