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Titolo:
Arrhythmogenic activity of cardiac muscle in pulmonary veins of the dog: implication for the genesis of atrial fibrillation
Autore:
Chen, YJ; Chen, SA; Chang, MS; Lin, CI;
Indirizzi:
Natl Def Med Ctr, Inst Pharmacol, Taipei, Taiwan Natl Def Med Ctr TaipeiTaiwan Med Ctr, Inst Pharmacol, Taipei, Taiwan Natl Def Med Ctr, Dept Biomed Engn, Taipei, Taiwan Natl Def Med Ctr Taipei Taiwan ed Ctr, Dept Biomed Engn, Taipei, Taiwan Natl Yang Ming Univ, Vet Gen Hosp, Sch Med, Dept Med, Taipei, Taiwan Natl Yang Ming Univ Taipei Taiwan sp, Sch Med, Dept Med, Taipei, Taiwan Natl Yang Ming Univ, Vet Gen Hosp, Sch Med, Inst Clin Med, Taipei, Taiwan Natl Yang Ming Univ Taipei Taiwan ch Med, Inst Clin Med, Taipei, Taiwan Taipei Med Univ, Affiliated Wan Fang Hosp, Taipei, Taiwan Taipei Med UnivTaipei Taiwan Affiliated Wan Fang Hosp, Taipei, Taiwan
Titolo Testata:
CARDIOVASCULAR RESEARCH
fascicolo: 2, volume: 48, anno: 2000,
pagine: 265 - 273
SICI:
0008-6363(200011)48:2<265:AAOCMI>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
ELECTROPHYSIOLOGICAL CHARACTERISTICS; RADIOFREQUENCY ABLATION; TACHYCARDIA; MODEL; REFRACTORINESS; INITIATION; HUMANS;
Keywords:
supraventr. arrhythmia; membrane potential; arrhythmia (mechanisms); impulse formation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Lin, CI Natl Def Med Ctr, Inst Pharmacol, Taipei, Taiwan Natl Def Med CtrTaipei Taiwan , Inst Pharmacol, Taipei, Taiwan
Citazione:
Y.J. Chen et al., "Arrhythmogenic activity of cardiac muscle in pulmonary veins of the dog: implication for the genesis of atrial fibrillation", CARDIO RES, 48(2), 2000, pp. 265-273

Abstract

Objective: Pulmonary veins are important foci of ectopic beats to initiateparoxysmal atrial fibrillation. The purpose of this study were to investigate the electrophysiological characteristics of excitable cells in canine pulmonary veins obtained from healthy and chronic rapid atrial pacing dogs and their responses to cardioactive agents. Methods: Transmembrane action potentials (APs) were recorded from multiple sites of pulmonary veins isolated from 17 healthy dogs and 14 dogs with chronic (6-8 weeks) rapid atrial pacing (780 bpm). Results: In normal superfusate, several types of electricalactivities were identified, including silent electrical activity, fast response APs driven by electrical stimulation, and spontaneous fast or slow response APs (with or without early afterdepolarizations). The incidences of AP with an early afterdepolarization (93% versus 41%) was greater in chronic pacing dogs. The spontaneous activities were depressed by beta-adrenoceptor blocker, calcium channel blocker, adenosine and acetylcholine. High frequency (>8 Hz) irregular rhythms occurred spontaneously or were induced by cardioactive agents or electrical stimuli. The incidence of spontaneously occurring tachyarrhythmias was much higher in preparations from chronic pacing dogs (93%) than from control (12%). The tachyarrhythmias were suppressed by sodium channel blocker, potassium channel blocker or magnesium. Conclusions: Pulmonary veins have arrhythmogenic ability through spontaneous activities or high-frequency irregular rhythms. The higher incidence of spontaneously occurring high-frequency irregular rhythms in chronic rapid atrial pacing dogs may account for the increased risk of atrial fibrillation in thesedogs. (C) 2000 Elsevier Science B.V. All rights reserved.

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Documento generato il 12/07/20 alle ore 12:16:36