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Titolo:
Association of Chlamydia pneumoniae immunoglobulin A seropositivity and risk of lung cancer
Autore:
Jackson, LA; Wang, SP; Nazar-Stewart, V; Grayston, JT; Vaughan, TL;
Indirizzi:
Fred Hutchinson Canc Res Ctr, Ctr Hlth Studies, Seattle, WA 98101 USA FredHutchinson Canc Res Ctr Seattle WA USA 98101 , Seattle, WA 98101 USA Fred Hutchinson Canc Res Ctr, Grp Hlth Cooperat Puget Sound, Seattle, WA 98101 USA Fred Hutchinson Canc Res Ctr Seattle WA USA 98101 , Seattle, WA 98101 USA Fred Hutchinson Canc Res Ctr, Program Epidemiol, Seattle, WA 98101 USA Fred Hutchinson Canc Res Ctr Seattle WA USA 98101 , Seattle, WA 98101 USA Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 ept Epidemiol, Seattle, WA 98195 USA Univ Washington, Dept Pathobiol, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 ept Pathobiol, Seattle, WA 98195 USA Univ Washington, Sch Publ Hlth & Community Med, Seattle, WA 98195 USA UnivWashington Seattle WA USA 98195 Community Med, Seattle, WA 98195 USA
Titolo Testata:
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
fascicolo: 11, volume: 9, anno: 2000,
pagine: 1263 - 1266
SICI:
1055-9965(200011)9:11<1263:AOCPIA>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
HELICOBACTER-PYLORI INFECTION; SEROLOGICAL EVIDENCE; GASTRIC-CANCER; HEART-DISEASE; ATHEROSCLEROSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Jackson, LA Fred Hutchinson Canc Res Ctr, Ctr Hlth Studies, 1730 Minor Ave,Suite 1600,Seattle, WA 98101 USA Fred Hutchinson Canc Res Ctr 1730 Minor Ave,Suite 1600 Seattle WA USA 98101
Citazione:
L.A. Jackson et al., "Association of Chlamydia pneumoniae immunoglobulin A seropositivity and risk of lung cancer", CANC EPID B, 9(11), 2000, pp. 1263-1266

Abstract

Chlamydia pneumoniae is a common respiratory pathogen that has also been associated with risk for chronic diseases, including atherosclerotic cardiovascular disease. Two recent studies have reported an association between serological evidence of past infection with the organism and lung cancer. To further evaluate this association, we conducted a case-control study among a subgroup of white male smokers identified for a population-based case-control study of lung cancer in western Washington between 1993 and 1995, Serum specimens obtained at study enrollment from 143 cases and 147 controls were tested for C. pneumoniae IgG, IgM, and IgA antibodies. In multivariate analysis controlling for smoking variables and educational status, IgA antibody titer greater than or equal to 16 was independently associated with risk of lung cancer among subjects <60 years of age [odds ratio (OR), 2.67; 95% confidence interval (CI), 1.21-5.89] but not among older subjects (OR, 0.69; 95% CI, 0.34-1.43), Among subjects <60 years of age, there was suggestive evidence of a stronger association among current smokers (OR 4.31; 95% CI, 1.36-13.68) than former smokers (OR 1.50; 95% CI, 0.48-4.75; P for interaction term, 0.26), Additional studies, including prospective serological evaluations, are needed to further assess the possible significance of this association.

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Documento generato il 24/09/20 alle ore 19:51:32