Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Striatal and extra-striatal D-2/D-3 dopamine receptor occupancy by quetiapine in vivo - [I-123]-epidepride single photon emission tomography (SPET) study
Autore:
Stephenson, CME; Bigliani, V; Jones, HM; Mulligan, RS; Acton, PD; Visvikis, D; Ell, PJ; Kerwin, RW; Pilowsky, LS;
Indirizzi:
Inst Psychiat, Dept Psychol Med, Sect Neurochem Imaging, London SE5 8AF, England Inst Psychiat London England SE5 8AF em Imaging, London SE5 8AF, England UCL, Middlesex Hosp, Sch Med, Inst Nucl Med, London, England UCL London England dlesex Hosp, Sch Med, Inst Nucl Med, London, England Univ Penn, Dept Radiol, Philadelphia, PA 19104 USA Univ Penn PhiladelphiaPA USA 19104 pt Radiol, Philadelphia, PA 19104 USA
Titolo Testata:
BRITISH JOURNAL OF PSYCHIATRY
, volume: 177, anno: 2000,
pagine: 408 - 415
SICI:
0007-1250(200011)177:<408:SAEDDR>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
I-123 EPIDEPRIDE; ANTIPSYCHOTIC-DRUGS; HUMAN-BRAIN; SCHIZOPHRENIA; CLOZAPINE; BINDING; SCALE; RELEASE; PET;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Stephenson, CME Inst Psychiat, Dept Psychol Med, Sect Neurochem Imaging, De Crespigny Pk,Denmark Hill, London SE5 8AF, England Inst Psychiat De Crespigny Pk,Denmark Hill London England SE5 8AF
Citazione:
C.M.E. Stephenson et al., "Striatal and extra-striatal D-2/D-3 dopamine receptor occupancy by quetiapine in vivo - [I-123]-epidepride single photon emission tomography (SPET) study", BR J PSYCHI, 177, 2000, pp. 408-415

Abstract

Background Selective action at limbic cortical dopamine D-2-like receptorscould mediate atypical antipsychotic efficacy with few extrapyramidal side-effects. Aims To test-the hypothesis that quetiapine has 'limbic selective' D-2/D-3receptor occupancy in vivo. Method The high-affinity D-2/D-3 ligand [I-123]-epidepride and single photon emission tomography were used to estimate D-2/D-3 specific binding and an index of relative percentage D-2/D-3 occupancy in striatal and temporal cortical regions for quetiapine-treated patients (n=6). Quetiapine-, and previously studied typical-antipsychotic- and clozapine-treated patients were compared. Results Mean (s.d) relative percentage D-2/D-3 receptor occupancy by quetiapine was 32.0% (14.6) in striatum and 60.1% (17.2) in temporal cortex (mean daily dose 450 mg: range 300-700 mg/day). Quetiapine treatment resulted in limbic selective D-2/D-3 blockade similar to clozapine and significantly higher than typical antipsychotics. Conclusions Preliminary data suggest that limbic selective D-2/D-3 receptor blockade is important for atypical drug action. Declaration of interest C.M.E.S. and H.M.J. were supported by research grants from AstraZeneca, V.B. by a research grant from Eli Lilly and R.S.M. bya UK Medical Research Council (MRC) Senior Clinical Research Fellowship Award. LS.P. is a UK MRC Senior Clinical Research Fellow.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 19:19:06