Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Chondroitin sulphate inhibits connective tissue mast cells
Autore:
Theoharides, TC; Patra, P; Boucher, W; Letourneau, R; Kempuraj, D; Chiang, G; Jeudy, S; Hesse, L; Athanasiou, A;
Indirizzi:
Tufts Univ, Sch Med, Dept Pharmacol & Expt Therapeut, Boston, MA 02111 USATufts Univ Boston MA USA 02111 col & Expt Therapeut, Boston, MA 02111 USA New England Med Ctr, Dept Obstet & Gynecol, Boston, MA 02111 USA New England Med Ctr Boston MA USA 02111 t & Gynecol, Boston, MA 02111 USA
Titolo Testata:
BRITISH JOURNAL OF PHARMACOLOGY
fascicolo: 6, volume: 131, anno: 2000,
pagine: 1039 - 1049
SICI:
0007-1188(200011)131:6<1039:CSICTM>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
VASCULAR SMOOTH-MUSCLE; NECROSIS-FACTOR-ALPHA; SECRETORY GRANULE PROTEOGLYCANS; BASOPHILIC LEUKEMIA-CELLS; INDUCED HISTAMINE-RELEASE; ANTIGEN-INDUCED AIRWAY; DIFFERENTIAL RELEASE; SUBSTANCE-P; MEDIATOR RELEASE; COMPOUND 48/80;
Keywords:
chondroitin sulphate; disodium cromoglycate; heparin; histamine; mast cells; proteoglycans; secretion;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
120
Recensione:
Indirizzi per estratti:
Indirizzo: Theoharides, TC Tufts Univ, Sch Med, Dept Pharmacol & Expt Therapeut, 136 Harrison Ave, Boston, MA 02111 USA Tufts Univ 136 Harrison Ave Boston MA USA 02111 02111 USA
Citazione:
T.C. Theoharides et al., "Chondroitin sulphate inhibits connective tissue mast cells", BR J PHARM, 131(6), 2000, pp. 1039-1049

Abstract

1 Mast cells derive from the bone marrow and are responsible for the development of allergic and possibly inflammatory reactions. Mast cells are stimulated by immunoglobulin E (IgE) and specific antigen, but also by a numberof neuropeptides such as neurotensin (NT), somatostatin or substance P (SP), to secrete numerous pro-inflammatory molecules that include histamine, cytokines and proteolytic enzymes.2 Chondroitin sulphate, a major constituent of connective tissues and of mast cell secretory granules, had a dose-dependent inhibitory effect on rat peritoneal mast cell release of histamine induced by the mast cell secretagogue compound 48/80 (48/80). This inhibition was stronger than that of the clinically available mast cell 'stabilizer' disodium cromoglycate (cromolyn). Inhibition by chondroitin sulphate increased with the length of preincubation and persisted after the drug was washed off, while the effect of cromolyn was limited by rapid tachyphylaxis.3 Immunologic stimulation of histamine secretion from rat connective tissue mast cells (CTMC) was also inhibited, but this effect was weaker in umbilical cord-derived human mast cells and was absent in rat basophilic leukemia (RBL) cells which are considered homologous to mucosal mast cells (MMC). Oligo- and monosaccharides were not as effective as the polysaccharides.4 Inhibition, documented by light and electron microscopy, involved a decrease of intracellular calcium ion levels shown by confocal microscopy and image analysis. Autoradiography at the ultrastructural level showed that chondroitin sulphate was mostly associated with plasma and perigranular membranes.5 Chondroitin sulphate appears to be a potent mast cell inhibitor of allergic and nonimmune stimulation with potential clinical implications.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 05:13:21