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Titolo:
A 5-arm maze enables parallel measures of sustained visuo-spatial attention and spatial working memory in mice
Autore:
Durkin, TP; Beaufort, C; Leblond, L; Maviel, T;
Indirizzi:
Univ Bordeaux 1, CNRS UMR 5106, Lab Neurosci Cognitives, F-33405 Talence, France Univ Bordeaux 1 Talence France F-33405 gnitives, F-33405 Talence, France
Titolo Testata:
BEHAVIOURAL BRAIN RESEARCH
fascicolo: 1, volume: 116, anno: 2000,
pagine: 39 - 53
SICI:
0166-4328(20001115)116:1<39:A5MEPM>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
RADIAL-ARM MAZE; LONG RETENTION INTERVALS; SHORT-TERM-MEMORY; BASAL FOREBRAIN; PROACTIVE-INTERFERENCE; CORTICAL ACETYLCHOLINE; EXCITOTOXIC LESIONS; COGNITIVE FUNCTIONS; NICOTINIC BLOCKADE; DIVIDED ATTENTION;
Keywords:
cognition; sustained visuo-spatial attention; spatial working memory; delayed matching to sample; 5-arm maze; mouse;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Durkin, TP Univ Bordeaux 1, CNRS UMR 5106, Lab Neurosci Cognitives, 1 Ave Fac, F-33405 Talence, France Univ Bordeaux 1 1 Ave Fac Talence France F-33405 lence, France
Citazione:
T.P. Durkin et al., "A 5-arm maze enables parallel measures of sustained visuo-spatial attention and spatial working memory in mice", BEH BRA RES, 116(1), 2000, pp. 39-53

Abstract

A 5-arm maze has been developed to provide parallel tests of sustained visuo-spatial attention and spatial working memory in mice. C57B1/6 mice were trained to select, either by immediate response (attention) or by delayed-matching response (working memory), one target arm among the five open arms. For attention testing, mice were first trained to acquire the basic task in which one randomly selected baited arm remained lit until a choice was made. Criterion of > 80% correct with a response latency < 5 s was attained in 52-56 trials. Following this, attention was tested by using trials wherein light signal durations of 2, 1 or 0.5 s were intermixed to vary attentional load. In the working memory test, mice were submitted to a forced visit to a randomly selected baited arm during a presentation phase. Following a variable retention interval (R.I.), mice were replaced into the maze and rewarded for choosing this arm. Criterion of > 80% correct was attained in 35-40 trials and mice exhibited high levels of retention for R.I.s up to 4 h. Results validate the 5-arm maze for evaluation of both sustained visuo-spatial attention and spatial working memory in mice. Both the tasks are rapidly acquired and the 20% chance level provides high resolution for evaluating performance. This comparative strategy allows to dissociate attention andmemory and to reveal deficits in these processes during ageing or in knockout strains. The high level of retention performance over R.I.s of 4 h enables studies using pharmacological treatments differentially affecting the acquisition, encoding, retention or retrieval phases of working memory. Furthermore, functional brain imaging studies may be used to identify neuronal networks which are differentially activated during these distinct phases. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 14:10:11