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Titolo:
Effects of reward anticipation, reward presentation, and spatial parameters on the firing of single neurons recorded in the subiculum and nucleus accumbens of freely moving rats
Autore:
Martin, PD; Ono, T;
Indirizzi:
Coll France, LPPA, CNRS, F-75231 Paris 05, France Coll France Paris France 05 France, LPPA, CNRS, F-75231 Paris 05, France Toyama Med & Pharmaceut Univ, Fac Med, Dept Physiol, Sugitani, Toyama 93001, Japan Toyama Med & Pharmaceut Univ Sugitani Toyama Japan 93001 ama 93001, Japan
Titolo Testata:
BEHAVIOURAL BRAIN RESEARCH
fascicolo: 1, volume: 116, anno: 2000,
pagine: 23 - 38
SICI:
0166-4328(20001115)116:1<23:EORARP>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
VENTRAL TEGMENTAL AREA; HIPPOCAMPAL PLACE CELLS; UNIT-ACTIVITY; SELF-STIMULATION; STRIATAL NEURONS; PROJECTION; NAVIGATION; SYSTEM; TASK; POSTSUBICULUM;
Keywords:
subiculum; accumbens; striatum; medial forebrain bundle; information content; spatial; directional; running speed;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Martin, PD Coll France, LPPA, CNRS, 11 Pl Marcelin Berthelot, F-75231 Paris 05, France Coll France 11 Pl Marcelin Berthelot Paris France 05 5, France
Citazione:
P.D. Martin e T. Ono, "Effects of reward anticipation, reward presentation, and spatial parameters on the firing of single neurons recorded in the subiculum and nucleus accumbens of freely moving rats", BEH BRA RES, 116(1), 2000, pp. 23-38

Abstract

The subiculum is the major output of the hippocampal formation (involved in spatial processing). Subicular afferents innervate the nucleus accumbens,which is thought to integrate limbic reward information with motor output. Rats were chronically implanted with extra-cellular recording electrodes aimed at both structures to investigate the functional relationship between them. Animals were then trained on a spatial task in which they searched for random locations where they would receive rewarding medial forebrain bundle stimulation. At random times a cue tone was sounded, indicating that thereward location was in the center of the environment. Rats quickly learnedto run to the center upon hearing the tone in order to receive a reward. Simultaneously recorded groups of up to eight subicular and accumbens neurons were found to display alterations in firing rate after rewarding medial forebrain bundle stimulation. Moreover, neurons in both subiculum and accumbens displayed alterations in firing rate prior to arrival at the center during cued runs, i.e. they anticipated predictable rewards. Subicular and accumbens firing was also correlated with spatial location. However, neurons in accumbens were more likely to respond to task events, and these responseswere more varied, than those seen in subiculum. Thus, while convergence ofspatial and reward information occurs at the level of single cells in bothsubiculum and nucleus accumbens, these structures also display functional localization. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 19:08:47