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Titolo:
Immunogenetic background of patients with autoimmune fatigue syndrome
Autore:
Itoh, Y; Igarashi, T; Tatsuma, N; Imai, T; Yoshida, J; Tsuchiya, M; Murakami, M; Fukunaga, Y;
Indirizzi:
Nippon Med Sch, Dept Pediat, Bunkyo Ku, Tokyo 1138603, Japan Nippon Med Sch Tokyo Japan 1138603 diat, Bunkyo Ku, Tokyo 1138603, Japan
Titolo Testata:
AUTOIMMUNITY
fascicolo: 3, volume: 32, anno: 2000,
pagine: 193 - 197
SICI:
0891-6934(2000)32:3<193:IBOPWA>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
SYSTEMIC LUPUS-ERYTHEMATOSUS; JAPANESE PATIENTS; HLA-ANTIGENS;
Keywords:
human leukocyte antigen (HLA); autoimmune fatigue syndrome; chronic fatigue syndrome; antinuclear antibody; school refusal;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Itoh, Y Nippon Med Sch, Dept Pediat, Bunkyo Ku, 1-1-5 Sendagi, Tokyo 1138603, Japan Nippon Med Sch 1-1-5 Sendagi Tokyo Japan 1138603 o 1138603, Japan
Citazione:
Y. Itoh et al., "Immunogenetic background of patients with autoimmune fatigue syndrome", AUTOIMMUN, 32(3), 2000, pp. 193-197

Abstract

We have previously reported that approximately 50% of children with chronic nonspecific complaints were positive for antinuclear antibodies (ANA), and that a novel autoantibody to a 62kD protein (anti-Sa) was found in 40% ofthese ANA-positive patients. Therefore, we proposed a distinct disease entity termed autoimmune fatigue syndrome (AIFS), We hypothesized that if autoimmune mechanisms did play an important role in the pathogenesis of AIFS, it is possible that it is immunogenetically regulated as observed in other autoimmune disorders. In order to examine the immunogenetic background of AIFS patients, HLA-A, -B, -C, and -DR loci were analyzed serologically in 61 AIFS patients. AIFS was found to be positively associated with the class I antigen HLA-B61 and with the class II antigen HLA-DR9, with odds ratios of 2.77 (p = 0.015, P-corr = 0.48) and 2.60 (p = 0.013, P-corr = 0.17), respectively. A negative association was also found between AIFS and HLA-DR2 withodds ratio of 0.25 (p = 0.029, P-corr = 0.041). When comparing anti-Sa positive AIFS patients with healthy controls, the odds ratios associated with HLA-B61, DR9, and DR2 were 3.42 (p = 0.021, P-corr = 0.22), 3.96 (p = 0.0011, P-corr = 0.015), and 0.16 (p = 0.0022, P-corr = 0.031), respectively. Thus, the HLA associations observed in this study suggested that immunogenetic background might play a role in AIFS.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 14:16:51