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Titolo:
The length of the CTLA-4 microsatellite (AT)(N)-repeat affects the risk for type 1 diabetes
Autore:
Lowe, RM; Graham, J; Sund, G; Kockum, I; Landin-Olsson, M; Schaefer, JB; Torn, C; Lernmark, A; Dahlquist, G;
Indirizzi:
Univ Washington, Dept Med, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 ton, Dept Med, Seattle, WA 98195 USA
Titolo Testata:
AUTOIMMUNITY
fascicolo: 3, volume: 32, anno: 2000,
pagine: 173 - 180
SICI:
0891-6934(2000)32:3<173:TLOTCM>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
AUTOIMMUNE THYROID-DISEASE; GRAVES-DISEASE; ISLET CELL; MELLITUS; GENE; SUSCEPTIBILITY; POLYMORPHISM; ASSOCIATION; IDDM; POPULATION;
Keywords:
autoimmunity; T cells; diabetes genes; diabetes mellitus; insulin-dependent diabetes; IDDM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Lernmark, A Univ Washington, Dept Med, Hlth Sci Bldg,Rm K-165,Box 357710, Seattle, WA 98195 USA Univ Washington Hlth Sci Bldg,Rm K-165,Box 357710 Seattle WA USA 98195
Citazione:
R.M. Lowe et al., "The length of the CTLA-4 microsatellite (AT)(N)-repeat affects the risk for type 1 diabetes", AUTOIMMUN, 32(3), 2000, pp. 173-180

Abstract

CTLA-4 is important to down-regulating T cell responses and has been implicated in type 1 (insulin dependent) diabetes mellitus in both linkage and association studies. The aim of our study was to relate the polymorphic (AT), microsatellite in the 3' untranslated sequence of the CTLA-4 gene to diabetes risk. We studied 616 consecutively diagnosed 0-34 year-old Swedish patients and 502 matched controls by PCR-based genotyping to determine the length of the 3'-end (AT)(n)repeat region of the CTLA-4 gene and categorizing alleles as predominantly monomorphic short (S) or highly polymorphic (in length) long (L) alleles. The odds of type 1 diabetes of subjects with the L/L genotype was estimated to be 1.84 times that of subjects with the S/S genotype (95% CT 1.44-2.73, p=0.002). Further analysis of the long alleles, partitioned into intermediate (I) length and very long (VL) alleles, suggested that L alleles act recessively in conferring diabetes risk (p=0.0009). This study suggests that the 3'-end (AT), repeat region of the CTLA-4 gene represents a recessive risk factor for type 1 diabetes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 20:05:02