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Titolo:
Activation of clotting factors XI and IX in patients with acute myocardialinfarction
Autore:
Minnema, MC; Peters, RJG; de Winter, R; Lubbers, YPT; Barzegar, S; Bauer, KA; Rosenberg, RD; Hack, CE; ten Cate, H;
Indirizzi:
Acad Med Ctr, Dept Vasc Med, NL-1100 DE Amsterdam, Netherlands Acad Med Ctr Amsterdam Netherlands NL-1100 DE DE Amsterdam, Netherlands Acad Med Ctr, Dept Cardiol, NL-1100 DE Amsterdam, Netherlands Acad Med Ctr Amsterdam Netherlands NL-1100 DE DE Amsterdam, Netherlands Red Cross Blood Transfus Serv, Cent Lab, Clin & Expt Immunol Lab, Amsterdam, Netherlands Red Cross Blood Transfus Serv Amsterdam Netherlands terdam, Netherlands Dept Vet Affairs Med Ctr, W Roxbury, MA USA Dept Vet Affairs Med Ctr W Roxbury MA USA irs Med Ctr, W Roxbury, MA USA Beth Israel Deaconess Med Ctr, Mol Med Unit, Boston, MA 02215 USA Beth Israel Deaconess Med Ctr Boston MA USA 02215 t, Boston, MA 02215 USA MIT, Dept Biol, Cambridge, MA USA MIT Cambridge MA USAMIT, Dept Biol, Cambridge, MA USA Slotervaart Hosp, Dept Internal Med, Amsterdam, Netherlands Slotervaart Hosp Amsterdam Netherlands rnal Med, Amsterdam, Netherlands
Titolo Testata:
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
fascicolo: 11, volume: 20, anno: 2000,
pagine: 2489 - 2493
SICI:
1079-5642(200011)20:11<2489:AOCFXA>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
UNSTABLE ANGINA-PECTORIS; CORONARY-ARTERY DISEASE; TISSUE-FACTOR; IN-VIVO; FIBRINOLYSIS INHIBITOR; DEPENDENT INHIBITION; BLOOD-COAGULATION; FIBRINOPEPTIDE-A; THROMBIN; PLASMA;
Keywords:
coagulation; thrombosis; myocardial infarction; cardiovascular disease;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Minnema, MC Acad Med Ctr, Dept Vasc Med, F4-159-2,Meibergdreef 9,POB 22700, NL-1100 DEAmsterdam, Netherlands Acad Med Ctr F4-159-2,Meibergdreef 9,POB22700 Amsterdam Netherlands NL-1100 DE
Citazione:
M.C. Minnema et al., "Activation of clotting factors XI and IX in patients with acute myocardialinfarction", ART THROM V, 20(11), 2000, pp. 2489-2493

Abstract

In acute coronary events, plaque rupture and the subsequent formation of the catalytic tissue factor-factor VIIa complex is considered to initiate coagulation. It is unknown whether clotting factors XI and IX are activated in acute coronary events. Therefore, we prospectively investigated the activation of clotting factors XI and IX as well as activation of the contact system and the common pathway in 50 patients with acute myocardial infarction(AMI), in 50 patients with unstable angina pectoris (UAP), and in 50 patients with stable angina pectoris (SAP). Factor XIa-C1 inhibitor complexes, which reflect acute activation of factor XI, were detected in 24% of the patients with AMI, 8% of the patients with UAP, and 4% of the patients with SAP (P<0.05), whereas factor XIa-<alpha>(1)-antitrypsin complexes, which reflect chronic activation, were observed equally in all 3 study groups. FactorIX peptide levels were significantly higher in the patients with AMI and UAP compared with the patients with SAP (P<0.01). No differences regarding markers of the common pathway were demonstrated. Fibrinopeptide A levels were elevated in patients with AMI compared with patients with UAP and those with SAP (P<0.01). Factor XIIa- or kallikrein-C1 inhibitor complexes were not increased. In conclusion, this is the first demonstration of the activation of clotting factors XI and IX in patients with acute coronary syndromes. Because these clotting factors are considered to be important for continuous thrombin generation and clot stability, their activation might have clinical and therapeutic consequences.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 19:34:19