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Titolo:
Decreased susceptibility to diet-induced atherosclerosis in human apolipoprotein A-II transgenic mice
Autore:
Tailleux, A; Bouly, M; Luc, G; Castro, G; Caillaud, JM; Hennuyer, N; Poulain, P; Fruchart, JC; Duverger, N; Fievet, C;
Indirizzi:
Inst Pasteur, Dept Atherosclerose, F-59019 Lille, France Inst Pasteur Lille France F-59019 Atherosclerose, F-59019 Lille, France Inst Pasteur, INSERM, U325, F-59019 Lille, France Inst Pasteur Lille France F-59019 r, INSERM, U325, F-59019 Lille, France Ctr Rech Vitry Alfortville, Atherosclerosis Dept, Rhone Poulenc Rorer Gencell Div, Vitry Sur Seine, France Ctr Rech Vitry Alfortville Vitry Sur Seine France try Sur Seine, France
Titolo Testata:
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
fascicolo: 11, volume: 20, anno: 2000,
pagine: 2453 - 2458
SICI:
1079-5642(200011)20:11<2453:DSTDAI>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIGH-DENSITY-LIPOPROTEINS; CHOLESTEROL; PLASMA; METABOLISM; OVEREXPRESSION; DEFICIENCY; PARTICLES; LECITHIN; MUTATION; DISEASE;
Keywords:
atherosclerosis; transgenic mice; lipoproteins;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Tailleux, A Inst Pasteur, Dept Atherosclerose, 1 Rue Prof Calmette, F-59019 Lille, France Inst Pasteur 1 Rue Prof Calmette Lille France F-59019 France
Citazione:
A. Tailleux et al., "Decreased susceptibility to diet-induced atherosclerosis in human apolipoprotein A-II transgenic mice", ART THROM V, 20(11), 2000, pp. 2453-2458

Abstract

Studies performed in vivo have been controversial regarding the implication of human apolipoprotein (apo)A-II in the atherogoenic process. Expressionof human apoA-II in transgenic mice fed a chow diet leads to (1) a bimodaldistribution of high density lipoprotein (HDL) size as in humans, (2) a reduction in total cholesterol concentration that is mainly due to a reduction in non-HDL cholesterol level, and (3) a dramatic reduction in mouse endogenous apoA-I and apoA-II. After 20 weeks on an atherogenic diet, transgenicmice had reduced total cholesterol concentrations because of a reduction in cholesterol associated with all lipoprotein classes. Endogenous apoA-I and apoA-II were also dramatically decreased in transgenic mice. The mean area of atherosclerotic lesions was drastically decreased in transgenic mice (-44%, P=0.0027) compared with control mice. The amount of aortic surface covered by lesions was positively correlated with very low density lipoprotein cholesterol (P<0.01) and intermediate density lipoprotein cholesterol levels (P<0.05). Transgenic mice were protected against the development of atherosclerosis despite a marked decrease in HDL cholesterol and apoA-I concentrations. This protection may be related to the marked reduction in circulating low density lipoprotein (very low density and intermediate density lipoprotein) levels in transgenic mice.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 12:15:19