Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Bezafibrate increases pre beta 1-HDL at the expense of HDL2b in hypertriglyceridemia
Autore:
Miida, T; Sakai, K; Ozaki, K; Nakamura, Y; Yamaguchi, T; Tsuda, T; Kashiwa, T; Murakami, T; Inano, K; Okada, M;
Indirizzi:
Niigata Univ, Sch Med, Dept Lab Med, Niigata 9518510, Japan Niigata Univ Niigata Japan 9518510 Dept Lab Med, Niigata 9518510, Japan Niigata Univ, Sch Med, Dept Internal Med 1, Niigata 9518510, Japan NiigataUniv Niigata Japan 9518510 nternal Med 1, Niigata 9518510, Japan Kido Hosp, Dept Cardiol, Niigata, Japan Kido Hosp Niigata JapanKido Hosp, Dept Cardiol, Niigata, Japan St Marianna Univ, Sch Med, Inst Med Sci, Kawasaki, Kanagawa, Japan St Marianna Univ Kawasaki Kanagawa Japan Sci, Kawasaki, Kanagawa, Japan Tokushima Bunri Univ, Dept Pharmaceut Care & Clin Pharm, Tokushima, Japan Tokushima Bunri Univ Tokushima Japan are & Clin Pharm, Tokushima, Japan
Titolo Testata:
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
fascicolo: 11, volume: 20, anno: 2000,
pagine: 2428 - 2433
SICI:
1079-5642(200011)20:11<2428:BIPB1A>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIGH-DENSITY-LIPOPROTEIN; APOLIPOPROTEIN-A-I; LECITHIN-CHOLESTEROL ACYLTRANSFERASE; CELL-DERIVED CHOLESTEROL; CORONARY-ARTERY DISEASE; ESTER TRANSFER PROTEIN; HUMAN PLASMA; HEPATIC LIPASE; EFFLUX; ESTERIFICATION;
Keywords:
pre-beta-HDL; hepatic lipase; apolipoprotein A-I; LpA-I; cholesteryl ester transfer protein;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Miida, T Niigata Univ, Sch Med, Dept Lab Med, Asahimachi 1-757, Niigata 9518510, Japan Niigata Univ Asahimachi 1-757 Niigata Japan 9518510 18510, Japan
Citazione:
T. Miida et al., "Bezafibrate increases pre beta 1-HDL at the expense of HDL2b in hypertriglyceridemia", ART THROM V, 20(11), 2000, pp. 2428-2433

Abstract

Pre beta1-high density lipoprotein (pre beta1-HDL), the initial acceptor of cell-derived cholesterol, can be generated from HDL2 by hepatic lipase. Because bezafibrate elevates lipase activity, it may increase pre beta1-HDL at the expense of HDL2. To answer this question, we determined the apolipoprotein A-I (apoA-I) distribution in 20 hypertriglyceridemics (triglycerides>2.26 mmol/L) and 20 sex-matched normolipidemics by native 2-dimensional gel electrophoresis. At baseline, pre beta1-HDL was 70% higher in hypertriglyceridemics than in normolipidemics (123.5+/-49.9 versus 72.5+/-34.1 mg/L apoA-I, P<0.01). Pre<beta>1-HDL was positively correlated with triglyceride (r=0.624, P<0.0001). A 4-week bezafibrate treatment (400 mg daily) increasedpre<beta>1-HDL by 30% (160.2+/-6415 mg/L apoA-I, P<0.05) but decreased HDL2b by 31% (from 188.8+/-94.9 to 129.3+/-78.7 mg/L apoA-I, P<0.05). Hepatic lipase activity increased by 24% (P<0.005); Pre<beta>1-HDL was generated either from ultracentrifugally isolated HDL2 or from plasma during incubationwith triglyceride lipase. In conclusion, bezafibrate increases pre beta1-HDL at the expense of HDL2. We speculate that such an effect might partly contribute to the antiatherogenic action of bezafibrate.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 11:28:23