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Titolo:
DNA segregation in bacteria
Autore:
Gordon, GS; Wright, A;
Indirizzi:
Tufts Univ, Dept Mol Biol & Microbiol, Boston, MA 02111 USA Tufts Univ Boston MA USA 02111 Mol Biol & Microbiol, Boston, MA 02111 USA
Titolo Testata:
ANNUAL REVIEW OF MICROBIOLOGY
, volume: 54, anno: 2000,
pagine: 681 - 708
SICI:
0066-4227(2000)54:<681:DSIB>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
P1 PLASMID PARTITION; SITE-SPECIFIC RECOMBINATION; INTEGRATION HOST FACTOR; ESCHERICHIA-COLI-CELLS; HISTONE-LIKE PROTEIN; LACKING HU PROTEIN; MINI-F PLASMID; BACILLUS-SUBTILIS; CHROMOSOME SEGREGATION; PARB PROTEIN;
Keywords:
chromosome; plasmid; partition; cellular localization;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
136
Recensione:
Indirizzi per estratti:
Indirizzo: Gordon, GS Tufts Univ, Dept Mol Biol & Microbiol, Boston, MA 02111 USA Tufts Univ Boston MA USA 02111 Microbiol, Boston, MA 02111 USA
Citazione:
G.S. Gordon e A. Wright, "DNA segregation in bacteria", ANN R MICRO, 54, 2000, pp. 681-708

Abstract

Segregation of DNA in bacterial cells is an efficient process that assuresthat every daughter cell receives a copy of genomic and plasmid DNA. In this review, we focus primarily on observations in recent years, including the visualization of DNA and proteins at the subcellular level, that have begun to define the events that separate DNA molecules. Unlike the process of chromosome segregation in higher cells, segregation of the bacterial chromosome is a continuous process in which chromosomes are separated as they arereplicated. Essential to separation is the initial movement of sister origins to opposite ends of the cell. Subsequent replication and controlled condensation of DNA are the driving forces that move sister chromosomes towardtheir respective origins, which establishes the polarity required for segregation. Final steps in the resolution and separation of sister chromosomesoccur at the replication terminus, which is localized at the cell center. In contrast to the chromosome, segregation of low-copy plasmids, such as Escherichia coli F, P1, and R1, is by mechanisms that resemble those used ineukaryotic cells. Each plasmid has a centromere-like site to which plasmid-specified partition proteins bind to promote segregation. Replication of plasmid DNA, which occurs at the cell center, is followed by rapid partitionprotein-mediated separation of sister plasmids, which become localized at distinct sites on either side of the division plane. The fundamental similarity between chromosome and plasmid segregation-placement of DNA to specific cell sites-implies an underlying cellular architecture to which both DNA and proteins refer.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 00:07:14