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Titolo:
Evaluation of coronary blood flow reserve by N-13-NH3 positron emission computed tomography (PET) with dipyridamole in the treatment of hypertension with the ACE inhibitor (Cilazapril)
Autore:
Masuda, D; Nohara, R; Tamaki, N; Hosokawa, R; Inada, H; Hirai, T; Chen, LG; Tadamura, E; Kudou, T; Konishi, J; Fujita, M; Sasayama, S;
Indirizzi:
Kyoto Univ, Grad Sch Med, Dept Cardiovasc Med, Sakyo Ku, Kyoto 6068507, Japan Kyoto Univ Kyoto Japan 6068507 ovasc Med, Sakyo Ku, Kyoto 6068507, Japan Hokkaido Univ, Dept Nucl Med, Sapporo, Hokkaido 060, Japan Hokkaido Univ Sapporo Hokkaido Japan 060 ed, Sapporo, Hokkaido 060, Japan Kyoto Univ, Dept Nucl Med, Kyoto, Japan Kyoto Univ Kyoto JapanKyoto Univ, Dept Nucl Med, Kyoto, Japan
Titolo Testata:
ANNALS OF NUCLEAR MEDICINE
fascicolo: 5, volume: 14, anno: 2000,
pagine: 353 - 360
SICI:
0914-7187(200010)14:5<353:EOCBFR>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
LEFT-VENTRICULAR HYPERTROPHY; MYOCARDIAL PERFUSION; MICROVASCULAR DISEASE; DIASTOLIC FUNCTION; TERM TREATMENT; RATS; MECHANISM; QUANTIFICATION; RESISTANCE; RESPONSES;
Keywords:
coronary flow reserve; angiotensin-converting enzyme inhibitor; positron emission computed tomography; hypertension; cilazapril;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Nohara, R Kyoto Univ, Grad Sch Med, Dept Cardiovasc Med, Sakyo Ku, 54 Kawaracho, Kyoto 6068507, Japan Kyoto Univ 54 Kawaracho Kyoto Japan 6068507 yoto 6068507, Japan
Citazione:
D. Masuda et al., "Evaluation of coronary blood flow reserve by N-13-NH3 positron emission computed tomography (PET) with dipyridamole in the treatment of hypertension with the ACE inhibitor (Cilazapril)", ANN NUCL M, 14(5), 2000, pp. 353-360

Abstract

Purpose: The purpose of this study was to evaluate the effect of treatmentwith an angiotensin-converting enzyme (ACE) inhibitor (Cilazapril) for early hypertensive patients in terms of coronary blood now reserve evaluated by (NH3)-N-13-positron emission tomography (PET). Methods: Before and after 12 weeks of ACE inhibitor treatment, (NH3)-N-13-PET with dipyridamole provocation test was performed, and definite myocardial perfusion and coronary Row reserve (CFR) were calculated. Results: Compared to our normal subjects previously reported (2.61 +/- 0.74), average coronary flow reserve was decreased (1.70 +/- 0.64 in hypertensive patients), and improved after treatment (1.77 +/- 0.52), but not significantly. Of 12 patients, five (42%) showed improved coronary flow reserve from 1.34 to 1.99 without a significant change in the resting flow. Only onepatient (8%) showed deterioration after the ACE inhibitor treatment, The coronary vascular resistance (CVR) after ACE inhibitor treatment of the patients with CFR < 2.0 decreased significantly compared with those with CFR <greater than or equal to> 2.0 (p < 0.03). Conclusions: These results indicate that hypertensive patients at the early stage show decreased coronary flow reserve despite having normal resting flow. Treatment with an ACE inhibitor (Cilazapril) for 12 weeks improved coronary flow reserve in 42% of our patients. The CVR of the patients with CFR < 2.0 showed improvement compared to those with CFR greater than or equalto 2.0,This result indicates that an ACE inhibitor (e.g., Cilazapril) should be one of the choices fur improving CFR if hypertensive patients in early stageshow signs of ischemia or diastolic dysfunction, which may be one of the sequels of reserve restriction.

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Documento generato il 07/04/20 alle ore 22:42:50