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Titolo:
Blood and brain magnesium in inbred mice and their correlation with sleep quality
Autore:
Chollet, D; Franken, P; Raffin, Y; Malafosse, A; Widmer, J; Tafti, M;
Indirizzi:
Univ Geneva, Dept Psychiat, Biochem & Neurophysiol Unit, CH-1225 Geneva, Switzerland Univ Geneva Geneva Switzerland CH-1225 Unit, CH-1225 Geneva, Switzerland
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
fascicolo: 6, volume: 279, anno: 2000,
pagine: R2173 - R2178
SICI:
0363-6119(200012)279:6<R2173:BABMII>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
CULTURED RAT NEURONS; INTRACELLULAR MG2+; NMDA RECEPTOR; THERAPEUTIC IMPLICATIONS; CHANNEL; DEFICIENCY; STRESS; DETERMINANTS; ELECTROLYTES; MECHANISMS;
Keywords:
fragmentation; sleep deprivation; recovery;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Tafti, M Univ Geneva, Dept Psychiat, Biochem & Neurophysiol Unit, Chemin Petit Bel Air 2, CH-1225 Chene Bourg, Switzerland Univ Geneva Chemin Petit Bel Air 2 Chene Bourg Switzerland CH-1225
Citazione:
D. Chollet et al., "Blood and brain magnesium in inbred mice and their correlation with sleep quality", AM J P-REG, 279(6), 2000, pp. R2173-R2178

Abstract

A strong genetic component in the regulation of blood magnesium (Mg) levels has been demonstrated. The regulation and distribution of brain Mg levels, however, have never been assessed. Herein we report on the genetic variation of peripheral and central Mg levels in six inbred strains of mice. In addition, the possible involvement of Mg in sleep regulation was assessed byestablishing correlations between Mg and sleep parameters obtained before and after a 6-h sleep deprivation. Although genotype strongly determined blood Mg levels, it did not affect brain Mg, suggesting that central and peripheral Mg are regulated differently. Central Mg displayed a highly structure-specific distribution with frontal cortex having the highest and brain stem the lowest values. Whereas for the amount and distribution of baseline sleep only marginal correlations with Mg were found, Mg contents in four of nine brain structures were highly positively correlated with the length of slow-wave sleep episodes during recovery. This relationship suggests that higher levels of Mg in specific brain sites promote sleep quality as part ofa recovery process.

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Documento generato il 01/12/20 alle ore 07:48:12