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Titolo:
Patients with chronic idiopathic neutropenia of adults have increased serum concentrations of inflammatory cytokines and chemokines
Autore:
Papadaki, HA; Coulocheri, S; Eliopoulos, GD;
Indirizzi:
Univ Crete, Dept Haematol, Sch Med, Univ Hosp Heraklion, Heraklion, GreeceUniv Crete Heraklion Greece Med, Univ Hosp Heraklion, Heraklion, Greece Univ Athens, Sch Med, Biol Chem Lab, GR-11527 Athens, Greece Univ Athens Athens Greece GR-11527 iol Chem Lab, GR-11527 Athens, Greece
Titolo Testata:
AMERICAN JOURNAL OF HEMATOLOGY
fascicolo: 4, volume: 65, anno: 2000,
pagine: 271 - 277
SICI:
0361-8609(200012)65:4<271:PWCINO>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; ADHESION MOLECULES; PROGENITOR CELLS; GM-CSF; INTERLEUKIN-1; MARROW; GRANULOPOIESIS; LYMPHOCYTES; BIOLOGY; INVITRO;
Keywords:
chronic idiopathic neutropenia of adults; serum cytokines; interleukin-1 (IL-1); interleukin-6 (IL-6); interleukin-8 (IL-8); transforming growth factor-beta(1); (TGF-beta(1)); tumour necrosis factor-alpha (TNF-alpha); RANTES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Eliopoulos, GD Univ Crete, Dept Haematol, Sch Med, Univ Hosp Heraklion, POB 1352, Heraklion, Greece Univ Crete POB 1352 Heraklion Greece 2, Heraklion, Greece
Citazione:
H.A. Papadaki et al., "Patients with chronic idiopathic neutropenia of adults have increased serum concentrations of inflammatory cytokines and chemokines", AM J HEMAT, 65(4), 2000, pp. 271-277

Abstract

Serum levels of inflammatory cytokines and chemokines were measured in 132patients with chronic idiopathic neutropenia of adults (CINA) and 34 healthy Volunteers (controls) using commercially available micro-ELISA determination kits, We found that serum interleukin-1 beta (IL-1 beta), tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), transforming growth factor-beta (1) (TGF-beta (1)), and soluble tumor necrosis factor receptor p55 (sTNF-RI) were all significantly increased in CINA patients compared to controls. Individual cytokine values inversely correlated with the number of circulating neutrophils. Serum levels of interleukin-8 (IL-8) and RANTES, two potent chemokines for neutrophils and lymphocytes, respectively, were also significantly increased in the group of patients and they inversely correlated with the number of circulating neutrophils, Contrarily, serum levels of interleukin-l (IL-4), interferon-gamma (IFN gamma), soluble CD23 (sCD23), and soluble interleukin-a receptor (sIL-2R) did not show any significant change in the patients studied, We assume that CINA patients have increasedserum concentrations of inflammatory cytokines and chemokines mainly produced by activated macrophages, while they disclose normal levels of inflammatory molecules mainly released from activated lymphocytes. These findings provide further evidence for an underlying low-grade chronic inflammatory process in CINA patients, as we previously have suggested, If this chronic inflammation is really the cause of the disorder or it simply represents the result of neutropenia remains to be elucidated. (C) 2000 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 23:01:02