Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
How does interleukin 15 contribute to the pathogenesis of HTLV type 1-associated myelopathy/tropical spastic paraparesis?
Autore:
Azimi, N; Mariner, J; Jacobson, S; Waldmann, TA;
Indirizzi:
NCI, Metab Branch, NIH, Bethesda, MD 20892 USA NCI Bethesda MD USA 20892NCI, Metab Branch, NIH, Bethesda, MD 20892 USA NINDS, Viral Immunol Sect, NIH, Bethesda, MD 20892 USA NINDS Bethesda MD USA 20892 ral Immunol Sect, NIH, Bethesda, MD 20892 USA
Titolo Testata:
AIDS RESEARCH AND HUMAN RETROVIRUSES
fascicolo: 16, volume: 16, anno: 2000,
pagine: 1717 - 1722
SICI:
0889-2229(20001101)16:16<1717:HDI1CT>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
I-ASSOCIATED MYELOPATHY; CYTOTOXIC LYMPHOCYTES-T; LYMPHOTROPIC VIRUS; NEUROLOGICAL DISEASE; CELL LEUKEMIA; BETA-CHAIN; RECEPTOR; IL-15; PROLIFERATION; ACTIVATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Azimi, N NCI, Metab Branch, NIH, Bldg 10,Room 4N-102,10 Ctr Dr,MSC 1274, Bethesda, MD 20892 USA NCI Bldg 10,Room 4N-102,10 Ctr Dr,MSC 1274 Bethesda MD USA 20892
Citazione:
N. Azimi et al., "How does interleukin 15 contribute to the pathogenesis of HTLV type 1-associated myelopathy/tropical spastic paraparesis?", AIDS RES H, 16(16), 2000, pp. 1717-1722

Abstract

HTLV-1 is the etiological agent of a neurological disease named HAM/TSP that has clinical characteristics similar to those of multiple sclerosis (MS), The PBMC obtained from HAM/TSP patients undergo spontaneous proliferationin the absence of addition of any exogenous cytokines in an ex vivo culture. This spontaneous proliferation has been thought to be due to the proliferation of T cells. It was demonstrated that this proliferation is, In part,due to the production of IL-2 and its receptor (IL-2R alpha) by HTLV-1-infected T cells. In this review, we demonstrate that IL-15 production also contributes to the spontaneous proliferation of T cells obtained from HAM/TSPPBMC. We provide data indicating that IL-15 expression is elevated in HAM/TSP PBMC when compared to that of the normal donors. Furthermore, we demonstrate that IL-15 overexpression by HTLV-1 is due to Tax trans-activation ofits promoter and induction of NF-kappaB transcription factors. On the basis of these studies, we propose a model in which HTLV-1 infection of T cellsresults in the production of both IL-2 and IL-15 cytokines, growth factorsthat support the proliferation of T cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/10/20 alle ore 09:34:57