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Titolo:
Increased HTLV type 1 Tax-specific CD8(+) cells in HTLV type 1-associated myelopathy/tropical spastic paraparesis: Correlation with HTLV type 1 proviral load
Autore:
Kubota, R; Nagai, M; Kawanishi, T; Osame, M; Jacobson, S;
Indirizzi:
NINDS, Viral Immunol Sect, NIB, NIH, Bethesda, MD 20892 USA NINDS Bethesda MD USA 20892 mmunol Sect, NIB, NIH, Bethesda, MD 20892 USA Kagoshima Univ, Sch Med, Dept Internal Med 3, Kagoshima 8908520, Japan Kagoshima Univ Kagoshima Japan 8908520 l Med 3, Kagoshima 8908520, Japan
Titolo Testata:
AIDS RESEARCH AND HUMAN RETROVIRUSES
fascicolo: 16, volume: 16, anno: 2000,
pagine: 1705 - 1709
SICI:
0889-2229(20001101)16:16<1705:IHT1TC>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
I-ASSOCIATED MYELOPATHY; VIRUS TYPE-I; CYTOTOXIC LYMPHOCYTES-T; NEUROLOGICAL DISEASE; PERIPHERAL-BLOOD; CEREBROSPINAL-FLUID; HAM/TSP PATIENTS; SPINAL-CORD; ANTIBODIES; PHENOTYPE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Jacobson, S NINDS, Viral Immunol Sect, NIB, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA NINDS 9000 Rockville Pike Bethesda MD USA 20892 , MD 20892 USA
Citazione:
R. Kubota et al., "Increased HTLV type 1 Tax-specific CD8(+) cells in HTLV type 1-associated myelopathy/tropical spastic paraparesis: Correlation with HTLV type 1 proviral load", AIDS RES H, 16(16), 2000, pp. 1705-1709

Abstract

Less than 1% of individuals infected with the human T lymphotropic virus type 1 (HTLV-1) develop an inflammatory neurological disorder, termed HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), while the vast majority of those infected remain asymptomatic HTLV-1 carriers (ACs). The fundamental viroimmunological differences between these groups are not well understood. To address this issue, we have investigated HTLV-1-specific T cell responses and measured the proviral load in these groups. Frequencies of HTLV-1-specific CD8(+) cells were demonstrated to be significantly higher in HAM/TSP patients than in ACs by using intracellular cytokine staining and soluble divalent HLA-A2/Ig fusion protein loaded with HTLV-1 Tax 11-19 peptide. It is consistent with the observed increase in HTLV-1-specific cytotoxic T lymphocytes in HAM/TSP patients. These CD8(+) cells produced interferon (IFN)-gamma in recognition of HTLV-1 antigens bound to HLAs on the infected CD4(+) cells, Using phenotypic markers indicative for T cell differentiation, memory and/or effector HTLV-1 Tax-specific CD8(+) cells were found to be increased in HLA-A2 HAM/TSP patients. HTLV-1 proviral load was elevated in HAM/TSP patients when compared to ACs, In addition, the proviral load in HAM/TSP patients correlated with the frequency of HTLV-1-specific IFN-gamma (+) CD8(+) cells or Tax-HLA-A2/Ig(+)CD8(+) cells, especially with the effector cells. In contrast, the proviral load inversely correlated with memory cells. These results suggest that HTLV-1 antigens may continuouslystimulate HTLV-1-specific CD8(+) cells and differentiate them from memory cells into effector cells irt vivo. These differentiated HTLV-1-specific CD8(+) cells may play a role in the pathogenesis of HAM/TSP.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 11:56:45