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Titolo:
Coiled-coil motif as a structural basis for the interaction of HTLV type 1tax with cellular cofactors
Autore:
Chun, ACS; Zhou, Y; Wong, CM; Kung, HF; Jeang, KT; Jin, DY;
Indirizzi:
Univ Hong Kong, Inst Mol Biol, Hong Kong, Hong Kong, Peoples R China Univ Hong Kong Hong Kong Hong Kong Peoples R China Kong, Peoples R China NIAID, Mol Microbiol Lab, Bethesda, MD 20892 USA NIAID Bethesda MD USA 20892 ID, Mol Microbiol Lab, Bethesda, MD 20892 USA
Titolo Testata:
AIDS RESEARCH AND HUMAN RETROVIRUSES
fascicolo: 16, volume: 16, anno: 2000,
pagine: 1689 - 1694
SICI:
0889-2229(20001101)16:16<1689:CMAASB>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
LEUKEMIA-VIRUS TYPE-1; NF-KAPPA-B; PRIMARY HUMAN-LYMPHOCYTES; I TAX; TRANSACTIVATOR TAX; TRANSFORMING PROTEIN; MEDIATES INTERACTION; BZIP PROTEINS; T-LYMPHOCYTES; DNA-BINDING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Jin, DY Univ Hong Kong, Inst Mol Biol, 8-F Kadoorie Biol Sci Bldg,PokfulamRd, Hong Kong, Hong Kong, Peoples R China Univ Hong Kong 8-F Kadoorie BiolSci Bldg,Pokfulam Rd Hong Kong Hong Kong Peoples R China
Citazione:
A.C.S. Chun et al., "Coiled-coil motif as a structural basis for the interaction of HTLV type 1tax with cellular cofactors", AIDS RES H, 16(16), 2000, pp. 1689-1694

Abstract

Human T lymphotropic virus type 1 (HTLV-1) Tax is a multifunctional protein centrally involved in transcriptional regulation, cell cycle control, andviral transformation. The regulatory functions of Tax are thought to be mediated through protein-protein interaction with cellular cofactors, Previously we have identified several novel binding partners for Tax, including human mitotic checkpoint protein MAD1 (TXBP181), G-protein pathway suppressorGPS2 (TXBP31), and I kappaB kinase regulatory subunit IKK-gamma, Here we described two additional Tax partners, TXBP151 and TXBP121. A closer examination of the sequences of eight independent cellular Tax-binding proteins identified by us and others revealed that all of them share a single characteristic, a highly structured coiled-coil domain, We also noted that Tax and the Tax-binding coiled-coil proteins can homodimerize. Additionally, the same domain in Tax is responsible for interaction with different coiled-coil proteins, Taken together, our findings point to a particular coiled-coil structure as one of the Tax-recognition motifs, The interaction of Tax with aparticular subgroup of cellular coiled-coil proteins represents one mechanism by which Tax dysregulates cell growth and proliferation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 11:34:41